CAS: 206986-87-0; Sodium,(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-Dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-Yl]Pentanoate,Hydrate

该化合物是属于白酸类的化学化合物,其特点是三氢氧化物结构,包括三氢氧基结构,其特征包括位于铬酸脊的3,7和12个位置的氢氧气组;盐钠形式的存在表明它是钠离子复合体,在水环境中提高了溶性;作为水合物,该产品在晶体结构中含有水分子,这可能影响其稳定性和溶解性;该物质在生物系统中发挥着重要作用,特别是在脂肪的消化和吸收方面,并可能具有药物和生物化学方面的应用;其立体化学(3,5,7,12)结构的标志对其生物活动及其与细胞受体的相互作用至关重要.总体而言,Cholan-24-oic酸,钠盐,氢盐,水是生物和化学环境中的一个重要化合物.

结构式图片

合成工艺路线路线简述

    Sodium Choleate,Sodium;(4R)-4-[(3R,5R,8R,9R,10S,12S,13R,14S,17R)-3,12-Dihydroxy-8,10,13-Trimethyl-1,2,3,4,5,6,7,9,11,12,14,15,16,17-Tetradecahydrocyclopenta[a]Phenanthren-17-Yl]Pentanoate,Sodium Dodecyl-Sulfate,Sodium Hexyl Sulfate,Sodium octyl Sulphate,Sodium Pentane-1-Sulfonate,Sodium Taurocholate 反应生成胆盐3号
    参考文献:Compositions And Methods For Analyzing Biomolecules Using Mass Spectroscopy
    标题:Compositions And Methods For Analyzing Biomolecules Using Mass Spectroscopy
    摘要:本发明揭示了用于质谱分析的组合物和方法.所述组合物和方法涉及使用质谱分析分析蛋白质和其他生物高分子,尤其是基质辅助激光解吸飞行时间质谱(maldi-Tof Ms).

    海关参考信息

    专利信息


    专利号:US-2012190064-A1
    优先权日:2004-10-01
    标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
    发明人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
    权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
    摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

    专利号:US-2009209032-A1
    优先权日:2004-10-01
    标 题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

    专利号:EP-1848812-A2
    优先权日:2004-10-01
    标题:Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

    专利号:US-2006110788-A1
    优先权日:2004-10-01
    标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules

    专利号:WO-2006039622-A2
    优先权日:2004-10-01
    标 题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
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    合成参考文献


    参考文献:10.1007/s11095-011-0448-z
    摘要:Elsayed MMA, Cevc G. Turbidity Spectroscopy for Characterization of Submicroscopic Drug Carriers, Such as Nanoparticles and Lipid Vesicles: Size Determination. Pharmaceutical Research. 2011 May 17;28(9):2204–22. doi: 10.1007/s11095-011-0448-z.
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