CAS: 214360-48-2; 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Benzonitrile

上下游产品

2-Chlorobenzonitrile bis(pinacol)diborane 2,3-dimethyl-2,3-butane diol 2-Cyanophenylboronic acid 2,2'-(6-oxo-1-(1-phenylethyl)-1,6-dihydropyridazine-4,5-diyl)dibenzonitrile 6-aminophenanthridine phenanthridine 2'-bromo-[1,1'-biphenyl]-2-carbonitrile

邻羟基苯甲腈置于硫酰氟,Sodium Acetate,二异丙胺,Palladium Dichloride,2-二环己基磷-2,4,6-三异丙基联苯体系中,用 二氯甲烷,异丙醇 用作溶剂,化学反应 16.0H,反应生成2-苯甲腈硼酸频哪酯
参考文献:使用硫酰氟活化对苯酚进行硼基化
标题:使用硫酰氟活化对苯酚进行硼基化
摘要:硼酸酯作为有机合成中的关键原材料和中心中间体的应用越来越广泛.从高度丰富且可再生的原料中合成它们仍然很有趣.在这里,我们报告了一种从苯酚合成芳基/杂芳基硼酸酯的有效且一锅法.在该方法中,苯酚首先被硫酰氟活化形成芳基氟磺酸盐,然后与双(频哪醇)二硼发生钯催化的脱氧硼化反应,得到一系列硼酸酯.该方法表现出优异的官能团耐受性,适用于天然产物和现有药物分子的合成.此外,该方案还适用于生物质衍生的酚类的硼化,包括天然存在的和生物活性的化合物.尤其,小鼠乳腺癌细胞中的2 O 2 .
Doi:10.1039/d3Gc01923C

专利信息

专利号:US-7250510-B2
优先权日:2005-08-24
标 题:Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations
发明人：ORGAN MICHAEL G; O'BRIEN CHRISTOPHER J; KANTCHEV ASSAM ERIC B
权利人:TOTAL SYNTHESIS LTD
摘要:The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.