CAS: 408-35-5; Sodium Palmitate

该化合物是棕榈酸钠盐(C16H31O2Na),这种白色,蜡状固体广泛用作工业和化妆应用中的表面活性剂,乳化剂和稳定剂,其阴离子特性使其在肥皂配方中有效,有助于紫色稳定性和净化性能.在制药中,它作为平板润滑剂和粘合剂的发端器.化合物在水和乙醇中表现出良好的溶解性,有助于将其纳入水体系统.其高熔点(~270°C)确保加工产品的热稳定性.作为天然脂肪酸的生物降解衍生物,它在某些应用中为合成冲动剂提供了一种环境上有利的替代物.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    海关参考信息

    专利信息


    专利号:US-7498434-B2
    优先权日:2004-01-14
    标题:Two-phase method for the synthesis of selected pyrazolopyrimidines
    发明人:CANTRELL GARY LEE; MOSER FRANK WILLIAM; HALVACHS ROBERT EDWARD
    权利人:MALLINCKRODT INC
    摘要:An improved method of making a substituted pyrazolopyrimidine. The method comprises reacting a aminopyrazole compound or a salt thereof with a substituted 1-oxo-2-propenyl-arene(-heterocycle) or a salt thereof under acidic conditions in a reaction medium including a two-phase mixture of an aqueous solution and a water-immiscible organic liquid. Specific substituted pyrazolopyrimidines include N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide and N-methyl-N-(3-{3-[2-thienyl-carbonyl]-pyrazolo[1,5-a]-pyrimidin-7-yl}phenyl)acetamide.

    专利号:US-2025268860-A1
    优先权日:2021-10-22
    标 题 :Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin
    发明人:BERNARD PHILIPPE
    权利人:JR
    摘要:A composition comprising baicalin or a derivative thereof, more particularly in combination with chlorogenic acid or a derivative thereof, as well as the cosmetic use of such a composition and its medical applications.

    专利号:US-9051656-B2
    优先权日:2009-07-23
    标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor
    发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI
    权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC
    摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.

    专利号:WO-2023067251-A1
    优先权日:2021-10-22
    标 题:Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin

    专利号:US-2014186905-A1
    优先权日:2011-08-15
    标题 :Biotechnological synthesis process of organic compounds with the aid of an alkl gene product
    发明人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD
    权利人:SCHAFFER STEFFEN; GIELEN JASMIN; DECKER NICOLE; KIRCHNER NICOLE; HAAS THOMAS; POETTER MARKUS; HAEGER HARALD; EVONIK DEGUSSA GMBH
    摘要:Subject matter of the invention is a biotechnological process for the production of organic compounds with the aid of at least one alkL gene product.

    专利号:US-3799958-A
    优先权日:1971-07-21
    标题 :Ester synthesis for preparation of specific glycerides
    发明人:MITCHELL L
    权利人:ETHYL CORP
    摘要:DIPOLAR APROTIC SOLVENT SUCH AS DIMETHYL SULFOXIDE ARE EFFICACIOUSLY EMPLOYED IN THE REACTION OF ALKALI METAL CARBOXYLATES WITH ORGANIC HALIDES. FOR THE FORMATION OF SPECIFIC TRIGLYCERIDES, GLYCERYL MONO- OR DIHALIDES ARE PREFERABLY EMPLOYED. REACTION SEQUENCES HAVE BEEN DEVISED FOR PREPARATION OF TRIGLYCERIDES WHEREBY UNDESIRABLE ACYL GROUP MIGRATION DOES NOT OCCUR.
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    主要参考文献

    1. Fatima, S., Hu, X., Gong, R.-H., et al. Palmitic acid is an intracellular signaling molecule involved in disease development. Cell. Mol. Life Sci. 76(13), 2547-2557 (2019). 2. Santos, M.J., López-Jurado, M., Llopis, J., et al. Influence of dietary supplementation with fish oil on plasma fatty acid composition in coronary heart disease patients. Ann. Nutr. Metab. 39(1), 52-62 (1995). 3. Binker-Cosen, M.J., Richards, D., Oliver, B., et al. Palmitic acid increases invasiveness of pancreatic cancer cells AsPC-1 through TLR4/ROS/NF-κB/MMP-9 signaling pathway. Biochem. Biophys. Res. Commun. 484(1), 152-158 (2017). 4. Lee, J.Y., Sohn, K.H., Rhee, S.H., et al. Saturated fatty acids, but not unsaturated fatty acids, induced the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. The Journal of Biological Chemisty 276(20), 16683-16689 (2001). 5. Karasawa, T., Kawashima, A., Usui-Kawanishi, F., et al. Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages. Arterioscler. Thromb. Vasc. Biol. 38(4), 744-756 (2018). 6. Marwarha, G., Rostad, S., Lilek, J., et al. Palmitate increases β-site AβPP-cleavage enzyme 1 activity and amyloid-β genesis by evoking endoplasmic reticulum stress and subsequent C/EBP homologous protein activation. J. Alzheimers Dis. 57(3), 907-925 (2017). 7. Knowles, C.J., Cebova, M., and Pinz, I.M. Palmitate diet-induced loss of cardiac caveolin-3: A novel mechanism for lipid-induced contractile dysfunction. PLoS One 8(4), e61369 (2013). 8. Yi, L.-Z., He, J., Liang, Y.-Z., et al. Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA. FEBS Lett. 580(30), 6837-6845 (2006). 9. Kabagambe, E.K., Tsai, M.Y., Hopkins, P.N., et al. Erythrocyte fatty acid composition and the metabolic syndrome: A National Heart, Lung, and Blood Institute GOLDN study. Clin. Chem. 54(1), 154-162 (2008).

    合成参考文献


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    摘要:USITC. SYN ORG CHEM-U.S. PROD/SALES 1984 p.175
    摘要:Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 1151
    摘要:Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 176-7
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