三乙醇胺盐酸盐 200.0~205.0 °C,5.33 Kpa 条件下,反应生成 2-吗啉乙醇 参考文献:Some New Local Anesthetics Containing The Morpholine Ring 标题:Some New Local Anesthetics Containing The Morpholine Ring 摘要: DOI:10.1021/ja01358A049
专利号:US-7825244-B2 优先权日:2005-06-10 标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis 发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG 权利人:JANSSEN PHARMACEUTICA NV 摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.
专利号:US-12162849-B2 优先权日:2018-12-21 标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof 发明人:HOVEYDA HAMID; DUTHEUIL GUILLAUME 权利人:OGEDA SA 摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.
专利号:US-10005807-B2 优先权日:2013-04-12 标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides 发明人:CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA 权利人:GLYCOM AS 摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.
专利号:WO-2004089946-A1 优先权日:2003-04-07 标题:Microwave synthesis of mycophenolate 发明人:ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR 权利人:BIOCON LTD; ADHIKARY LAXMI; SURYANARAYAN SHRIKUMAR 摘要:A process for synthesis of a compound of formula (I) using microwave irradiation.
专利号:US-4855425-A 优先权日:1986-08-27 标题:Process for the selective synthesis of ethylene diamines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:The present invention is a process for the selective synthesis of alkanediamines by reacting a secondary amine with an alkanediol. High conversions and high selectivity for the production of alkanediamines is achieved by carrying out the reaction in the presence of a compound or complex of ruthenium in the absence of an organic phosphine co-catalyst.
专利号:US-5880295-A 优先权日:1994-02-16 标 题 :Process for the preparation of diamine intermediates useful in the synthesis of HIV protease inhibitors 发明人:KALTENBACH III ROBERT FRANK 权利人:DU PONT PHARM CO 摘要:The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas. ##STR1##
摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 409. 摘要:Acute Toxicity Data. Journal of the American College of Toxicology, Part B., 1(16), 1990 摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).