CAS: 67531-86-6; 2-Fluoro-6-Hydroxybenzoic Acid

相似化合物

140675-43-0 38226-10-7 72373-81-0

上下游产品

2-fluoro-6-(methoxymethoxy)benzoic acid 3-(fluorophenyloxy)triisopropylsilane carbon dioxide 1-fluoro-3-(methoxy-methoxy)benzene Methyl 2-fluoro-6-hydroxybenzoate 6-fluorosalicyl alcohol

3-氟苯酚置于咪唑,Potassium Tert-Butylate体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 22.0H,反应生成 2-氟-6-羟基苯甲酸
参考文献:将核心化合物转化为积木:区域化学穷举功能化的概念
标题:将核心化合物转化为积木:区域化学穷举功能化的概念
摘要:在模型研究中,3-氟苯酚和 3-氟吡啶通过相应的有机金属中间体转化为相应羧酸的所有可能的区域异构体.正如对调查结果进行概括的尝试所揭示的那样,一套有限的原则和方法足以应对所有性病.场景.用于区域化学的最有价值和通用的工具.多种底物模式的详尽功能化是可选的位点选择性金属化(通过试剂/底物匹配或外围配位控制),使用激活或拥塞保护基团和碱性梯度驱动的重卤素迁移(随后是卤素/金属排列).[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200400895

专利信息

专利号:WO-2024054881-A1
优先权日:2022-09-07
标题:Ligand-enabled scalable c-h hydroxylation of benzoic and phenylacetic acids at room temperature
发明人：YU JIN-QUAN; LI ZHEN; PARK HAN
权利人:SCRIPPS RESEARCH INST
摘要:The application discloses industry scalable methods of using bifunctional bidentate pyridone-carboxylic acid ligands, such as 2-methyl-2-(6-oxo-1,6-dihydropyridin-2-yl)propanoic acid, that enable room-temperature Pd-catalyzed C-H hydroxylation of a broad range of benzoic and phenylacetic acids with an industry-compatible oxidant, aqueous hydrogen peroxide, at room temperature. Further disclosed are methods of derivatization of the resulting hydroxylation products, synthesis of polyfluorinated natural products coumestan or pterocarpene from phenol building blocks, and hydroxylation of ibuprofen using this methodology,

专利号:US-11286270-B2
优先权日:2017-10-11
标 题:Boronic acid derivatives and synthesis thereof
发明人：HECKER SCOTT J; BOYER SERGE HENRI; DIELEMANS HUBERTUS J A; GONZALEZ DE CASTRO ANGELA; DE VRIES ANDREAS H M; LEFORT LAURENT
权利人:QPEX BIOPHARMA INC
摘要:Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).