1-乙基硫烷基-2-丁氧基-乙烷置于1,4-二氧六环,盐酸体系中,化学反应生成 2-氯乙基乙基硫醚 参考文献:Prileshaewa; Schostakowskii,Izvestiya Akademii Nauk Sssr,Seriya Khimicheskaya,1958,P. 1104,1109; Engl. Ausg. S. 1071,1075 标题:Prileshaewa; Schostakowskii,Izvestiya Akademii Nauk Sssr,Seriya Khimicheskaya,1958,P. 1104,1109; Engl. Ausg. S. 1071,1075
专利号:US-7808632-B2 优先权日:2006-07-27 标 题:Nanocomposite material for direct spectroscopic detection of chemical vapors 发明人:VAIDYA BIKAS; DRECHSLER ULF WERNER 权利人:LYNNTECH INC 摘要:Method and material for spectroscopic detection of organic chemicals. The material is a substantially optically transparent solid, such as ZnS, having a high surface area for adsorption of an analyte, such as organic chemical vapors. The solid material preferably has metal nanoparticles, such as gold, silver or copper nanoparticles, deposited on the surface for signal enhancement. A template compound, such as cetyl trimethyl ammonium bromide and alkoxylate block polymers, may be used during the material synthesis, such as reacting zinc chloride and sodium sulfide in the presence of the template compound, and later removed through calcination and washing to achieve the high surface area. The method of use includes collecting an analyte on the material and detecting the spectroscopic response of the analyte while it is collected on the surface. The mechanism of collection may include adsorbing, absorbing, and preconcentrating. Preferably, the spectroscopic response is selected from infrared spectra or ultraviolet-visible spectra.
专利号:US-2009048153-A1 优先权日:2004-12-03 标题:Composition for treating sulfur mustard toxicity and methods of using same 发明人:VARMA SHAMBHU D; PETRALI JOHN 权利人:UNIV MARYLAND; US GOV SEC ARMY 摘要:One embodiment of the present invention provides a composition, comprising, in amounts effective to treat sulfur mustard or half sulfur mustard induced toxicity or skin damage: an agent that inhibits alkylation of —SH and >NH protein groups; an agent that reduces —SS— to SH; a scavenger of reactive oxygen species; a substrate that maintains tissue reduction-oxidation status; an agent that protects against invading inflammatory cells and associated oxidative stress; an antagonist of prostaglandin synthesis; and an agent that induces tissue regeneration. Methods of using the composition are also provided.
专利号:US-11358133-B2 优先权日:2018-05-16 标题 :Metal ion-directed carboxylic acid functionalized polyoxometalate hybrid compounds and their preparation method and applications for catalyzing the degradation of chemical warfare agent simulants 发明人:AN HAIYAN; HOU YUJIAO 权利人:UNIV DALIAN TECH 摘要:Metal ion-directed carboxylic acid functionalized polyoxometalate hybrid compounds, and their preparation method and applications in catalyzing the degradation of chemical warfare agent simulants. In the synthesis, Na 2 MoO 4 , p-hydroxybenzonic acid (PHBA), alanine (Ala), KCl, transition metal cations and As 2 O 3 as raw materials and water are used as solvent. At room temperature, 2-chloroethyl ethyl sulfide (CEES) and the prepared polyoxometalate hybrid compounds were mixed together in anhydrous ethanol and stirred, and H 2 O 2 was subsequently added into the reaction system. The catalytic reaction for the degradation of CEES was finished within 5 min under stirring. In the catalytic hydrolysis of diethyl cyanophosphonate (DECP), the catalyst, DECP, DMF and H 2 O were put together and mixed fully. The prepared polyoxometalate hybrid compounds have the advantages of high conversion, high selectivity and easy recyclability in catalyzing the degradation of two types of chemical warfare agent simulant.
专利号:US-5202444-A 优先权日:1990-11-27 标题:Optically isomeric inositol and process for making optically active compound 发明人:OZAKI SHOICHIRO; AKIYAMA TAKAHIKO; KAGEYAMA KUNIO; MACHIDA MORIHISA 权利人:YOKOHAMA RUBBER CO LTD 摘要:Optically active diols and hydroxycarboxylic acids and their esters are produced by deriving 1L-1,2:5,6-di-O-cyclohexylidene-chiro-inositol from 1L-chiro-inositol as an asymmetric source, followed by introduction of a selected class of sterically hindering and asymmetrically reactive groups into the first-mentioned compound and by subsequent reduction of the resulting compound. Seven specific inositols are also derivable from synthesis of those ultimate compounds.
专利号:RU-2198879-C2 优先权日:1996-09-25 标题:Derivatives of quinazoline, methods of their synthesis, pharmaceutical compositions comprising thereof, method of attainment of antiangiogenic effect and/or effect of blood vessel permeability reduction in warm-blooded animal
专利号:CN-114560878-B 优先权日:2022-02-25 标题 :A class of carborane-benzothiazole derivatives and their synthesis methods and fluorescent sensing films based on them, preparation methods and applications
[参考文献]: Changcai Liu, Et Al. An Improved Method For Retrospective Quantification Of Sulfur Mustard Exposure By Detection Of Its Albumin Adduct Using Ultra-High Pressure Liquid Chromatography-Tandem Mass Spectrometry. Anal Bioanal Chem. 2015 Sep;407(23):7037-46. [参考文献]: Jessica Gadsden-Gray, Et Al. Induction Of Neuronal Damage In Guinea Pig Brain By Intratracheal Infusion Of 2-Chloroethyl Ethyl Sulfide, A Mustard Gas Analog. J Biochem Mol Toxicol. 2012 Jan;26(1):23-30. [参考文献]: Jonell N Smith, Et Al. Facility Monitoring Of Chemical Warfare Agent Simulants In Air Using An Automated, Field-Deployable, Miniature Mass Spectrometer. Rapid Commun Mass Spectrom. 2011 May 30;25(10):1437-44. [参考文献]: Kai Kehe, Et Al. Modified Immunoslotblot Assay To Detect Hemi And Sulfur Mustard Dna Adducts. Chem Biol Interact. 2013 Dec 5;206(3):523-8. [参考文献]: Paul R Houin, Et Al. Intratracheal Heparin Improves Plastic Bronchitis Due To Sulfur Mustard Analog. Pediatr Pulmonol. 2015 Feb;50(2):118-26.
合成参考文献
参考文献:10.1155/2011/109516 摘要:Paromov V, Kumari S, Brannon M, Kanaparthy NS, Yang H, Smith MG, Stone WL. Protective Effect of Liposome-Encapsulated Glutathione in a Human Epidermal Model Exposed to a Mustard Gas Analog. Journal of Toxicology. 2011;2011():1–11. doi: 10.1155/2011/109516.