CAS: 70415-50-8; 6-Chloro-4-Hydroxy-2-Methyl-2H-Thieno[2,3-E]-1,2-Thiazine-3-Carboxylic Acid Methyl Ester 1,1-Dioxide

上下游产品

methyl 5‐chloro‐3‐(methylsulfamoyl)thiophene‐2‐carboxylate bromoacetic acid methyl ester 6-chlorine-4-hydroxy-2-methyl-N-[2-(5'-methyl)thiazolyl]-2H-thieno-[2,3-e]-1,2-thiazine-3-formamide-1,1-dioxide methanol 6-Chloro-N-{4-[5-(4-fluorophenyl)-2-furanyl]-2-thiazolyl}-4-hydroxy-2-methyl-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide 6-Chloro-4-hydroxy-2-methyl-N-(4phenyl-2-thiazolyl)-2H-thieno[2,3-e]-1,2-thiazine-3-carboxamide 1,1-dioxide

Methyl 5-Chloro-3-(N-(2-Methoxy-2-Oxoethyl)-N-Methylsulfamoyl)Thiophene-2-Carboxylate 以79的收率获得产物6-氯-4-羟基-2-甲基-2H-噻吩[2,3-E]-1,2-噻嗪-3-甲酸甲酯-1,1-二氧化物
参考文献:一种氯诺昔康及中间体的制备方法
标题:一种氯诺昔康及中间体的制备方法
摘要:本发明涉及制备氯诺昔康的中间体和制备氯诺昔康一种新的制备方法.所述方法,包括以下步骤:以5-氯-3-氯磺酰基-2-噻吩羧酸甲酯为起始物料,由5-氯-3-氯磺酰基-2-噻吩羧酸甲酯与肌氨酸甲酯盐酸盐发生缩合反应,然后在甲醇钠溶液中发生环合反应,最后与2-氨基吡啶酰胺化反应生成氯诺昔康.本发明的制备方法原料易得,合成路线短,副产物少,毒性低,污染小,环境友好,产品纯度高,适合工业化生产.

专利信息

专利号:US-11697658-B2
优先权日:2020-12-25
标题:Method for preparing lornoxicam
发明人：LIU ZHEN; XING DONGYE; ZHANG ZHONGZHENG; LI JIE; Han Yangong; CUI YALI; WANG LIRU; LIU HONGLIANG; MI YAN; LI LI; TANG JINGANG; KANG YI
权利人:BEIJING JINCHENG TAIER PHARMACEUTICAL CO LTD
摘要:The present disclosure relates to the technical field of drug synthesis, in particular to a method for preparing lornoxicam. The method includes the following steps: using 6-chloro-4-hydroxy-2-methyl-2-H-thieno[2,3-e]-1,2-thiazine methyl carboxylate-1,1-dioxide and 2-aminopyridine as raw materials, and xylene as a solvent; mixing the raw material and solvent, and adding a stabilizer, to obtain a mixture; subjecting the mixture to an ammonolysis; cooling the resulting reactant; conducting a vacuum concentration to remove the solvent; adding an organic solvent and slurrying, and filtering, to obtain a crude lornoxicam; and refining the crude lornoxicam to obtain the lornoxicam. In the present disclosure, p-toluenesulfonic acid is used as a stabilizer to reduce the reaction temperature and promote the reaction to proceed forward, thereby improving the quality and yield of the product.

专利号:CN-1580059-A
优先权日:2003-08-01
标题:Synthesis method of 6-chloro-4-hydroxyl-2-methyl-2H-thieno(2,3-e)-1,2-thiazine-1,1-dioxide-3-carboxylate

专利号:CN-1266155-C
优先权日:2003-08-01
标题 :Synthesis method of 6-chloro-4-hydroxyl-2-methyl-2H-thieno(2,3-e)-1,2-thiazine-1,1-dioxide-3-carboxylate