CAS: 13679-70-4; 5-Methylthiophene-2-Carbaldehyde

相似化合物

1918-79-2 72835-25-7 19432-69-0

上下游产品

CAS号554-14-3 2-甲基噻吩 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号75-44-5 光气 | CAS号107-06-2 1,2-二氯乙烷 | CAS号93-61-8 N-甲基甲酰苯胺 | CAS号98-03-3 2-噻吩甲醛 | CAS号638-02-8 2,5-二甲基噻吩 | CAS号96-43-5 2-氯噻吩 | CAS号52380-98-0 5-methyl-thioph... | CAS号108-24-7 乙酸酐 | CAS号193202-86-7 1-[(5-methylthi... | CAS号23222-36-8 2-(5-methylthio... | CAS号1918-79-2 5-甲基-2-噻吩甲酸 | CAS号26421-32-9 2,5-二甲基噻吩-3-羧酸 | CAS号89776-66-9 2-氨基-2-(5-甲基-2-... | CAS号72835-25-7 5-甲基噻吩-2-甲腈 | CAS号59207-23-7 2-甲基-噻吩[3,2-c]吡... | CAS号638-02-8 2,5-二甲基噻吩 | CAS号157890-50-1 (5-methylthioph... | CAS号104163-34-0 2-氨甲基-5-甲基噻吩

2,5-二甲基噻吩置于三氯氧磷体系中,用 N,N-二甲基甲酰胺 用作溶剂,化学反应 8.0H,以84%的收率获得5-甲基-2-噻吩甲醛
参考文献:二芳基甲烷骨架的系统构效关系 (Sar) 探索和高效新型尿酸转运蛋白 1 (Urat1) 抑制剂的发现
标题:二芳基甲烷骨架的系统构效关系 (Sar) 探索和高效新型尿酸转运蛋白 1 (Urat1) 抑制剂的发现
摘要:为了系统地探索和更好地理解二芳基甲烷骨架在设计强效尿酸转运蛋白 1 (Urat1) 抑制剂时的构效关系 (Sar),设计并合成了 33 种化合物(1A-1X 和 1Ha-1Hi),并测定了它们的体外 Urat1 抑制活性 (Ic50).三轮系统的 Sar 探索导致发现了一种高效的新型 Urat1 抑制剂,1H,其效力分别比母体 Lesinurad 和苯溴马隆强 200 倍和 8 倍(ic50 = 0.035 μm 对人 Urat1 1 小时 Vs Lesinurad 和苯溴马隆分别为 7.18 μm 和 0.28 μm).化合物 1H 是迄今为止我们实验室发现的最有效的 Urat1 抑制剂,也可与目前正在临床试验中开发的最有效的抑制剂相媲美.
Doi:10.3390/molecules23020252

专利信息

专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人：FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:US-2022356139-A1
优先权日:2019-09-03
标 题:Synthesis of deuterated aldehydes
发明人：WANG WEI
权利人:ARIZONA BOARD OF REGENTS ON BEHALF OF ATHE UNIV OF ARIZONA
摘要:Described are methods for preparing a deuterated aldehyde using N-heterocyclic carbene catalysts in a solvent comprising D 2 O. The methods may be used to convert a wide variety of aldehydes (e.g., aryl, alkyl, or alkenyl aldehydes) to C-1 deuterated aldehydes under mild reaction conditions without functionality manipulation.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4837327-A
优先权日:1987-07-13
标 题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-9650329-B2
优先权日:2013-06-25
标题:Transition-metal-free N-arylation of tertiary amines using arynes
发明人：BIJU AKKATTU THANKAPPAN; BHOJGUDE SACHIN SURESH; KAICHARLA TRINADH
权利人:COUNCIL SCIENT IND RES; COUNCIL SCIENT IND RES
摘要:The present invention relates to transition-metal-free process for the synthesis of tertiary arylamines comprises coupling reaction between arynes and N,N-dimethyl aniline compounds in presence of 18-crown-6, KF and THF.