CAS: 1643-28-3; 3-(2-Chlorophenyl)Propionic Acid

相似化合物

7315-17-5 6282-87-7 55144-92-8

上下游产品

CAS号3752-25-8 2-氯肉桂酸 | CAS号611-19-8 邻氯氯苄 | CAS号105-53-3 丙二酸二乙酯 | CAS号30573-88-7 3-(2-氯苯基)丙酸乙酯 | CAS号74124-86-0 3-(2-氯苯基)丙酸甲酯 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号89-98-5 邻氯苯甲醛 | CAS号24393-51-9 (E)-3-(2-氯苯基)丙烯酸乙酯 | CAS号201230-82-2 carbon monoxide | CAS号495-78-3 3-(2-羟苯基)丙酸 | CAS号15115-61-4 4-氯-2,3-二氢-1H-茚 | CAS号553-03-7 3,4-二氢-2(1H)-喹啉酮 | CAS号69739-64-6 5-氯-β-四氢萘酮 | CAS号3199-69-7 2-BROMO-4-CHLOR... | CAS号3199-71-1 4-氯-2,3-二氢-1H-茚-1-醇 | CAS号15115-59-0 4-氯-1-茚满酮 | CAS号67120-40-5 4-氯-2,3-二氢-1H-茚-1-胺 | CAS号157433-36-8 3-(2-氯苯基)-丙醛 | CAS号74124-86-0 3-(2-氯苯基)丙酸甲酯

邻氯肉桂酸置于samarium Diiodide,叔丁醇体系中,用 四氢呋喃 用作溶剂,化学反应生成3-(2-氯苯基)丙酸
参考文献:肉桂酸的二碘化钐还原
标题:肉桂酸的二碘化钐还原
摘要:通过使用 Gc 或 Gc/ms 以及 HPLC 作为检测工具,测量 Smi2 还原率的方法扩展到更广泛的有机化合物.还原底物不仅限于水不溶性化合物或仅低沸点化合物.为此应用选择了高沸点的水溶性肉桂酸衍生物.在六甲基磷酰胺或叔丁醇存在下,Smi2 还原肉桂酸的绝对速率常数被认为是该反应中合适的质子源.速率取决于底物和添加剂,如: 速率 ∞ [t-Buoh][肉桂酸] 和速率 ∞ [hmpa][肉桂酸] α-甲基肉桂酸,2-甲基肉桂酸,4-甲基肉桂酸,2-甲氧基肉桂酸,3-甲氧基肉桂酸,4-甲氧基肉桂酸,
Doi:10.1002/jccs.200400136

专利信息

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:CN-112679336-A
优先权日:2020-12-29
标 题 :A kind of method of heterogeneous palladium metal catalyzed synthesis of phenylpropionic acid compounds

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:US-5648540-A
优先权日:1994-07-15
标 题 :Amine preparation
发明人：VANWAGENEN BRADFORD C; DUFF STEVEN R; NELSON WILLIAM A; D AMBRA THOMAS E
权利人:NPS PHARMA INC
摘要:A method of making (R)-N-[1-(3-methoxyphenyl)ethyl]-3-(2-chlorobenzene)propanamine which involves reducing the appropriate amidyl or iminyl precursor with an appropriate reducing agent. The appropriate amidyl or iminyl precursor is made from a synthesis involving the use of (R)-3-methoxy-α-methylbenzylamine. A method of condensing a nitrile with a primary or secondary amine to form an imine involves the reaction of a nitrile with diisobutylaluminum hydride; and then reacting the resultant compound with a primary or secondary amine to form the imine. The process is especially useful for producing enantiomerically pure chiral imines, and, ultimately, amines. Typical such imines have the formula: ##STR1## wherein R, R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, aryl and aralkyl.

专利号:CN-1242007-A
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising such compounds, and methods of inhibiting beta amyloid peptide release and/or its synthesis using such compounds