CAS: 18173-64-3; Tert-Butyldimethylsilanol

相似化合物

66548-21-8 17877-23-5 67875-55-2

上下游产品

tert-butyldimethylsilyl chloride 15H39NOSi3C15H39NOSi3 Hexamethylcyclotrisiloxane tert.-butyl lithiumO-(tert-butyldimethylsilyl)-N-(2-chloroethyl)carbamate 3-[(1,1-dimethylethyl)dimethylsilyl]oxycholest-5-ene >phenylcarbamateO-(tert-butyldimethylsilyl)-N-phenylcarbamate (4S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-3,4-dimethyl-5-phenyl-[1,3,2]oxazaphospholidine

T-Butyldimethylsilane置于2,2,2-三氟苯乙酮,双氧水体系中,用 乙腈,叔丁醇 用作溶剂,化学反应 0.5H,以96%的收率获得叔丁基二甲基硅烷醇
参考文献:有机硅烷的有机催化氧化为硅烷醇
标题:有机硅烷的有机催化氧化为硅烷醇
摘要:有机硅烷氧化为硅烷醇构成了工业界和学术界的诱人转变.绕过对化学计量的氧化剂或贵金属催化络合物的需求,已经完成了硅烷的第一有机催化氧化.催化量的2,2,2-三氟苯乙酮与绿色氧化剂h 2 O 2结合,可在较短的反应时间内达到极佳的定量收率.可以容许各种烷基,芳基,烯基和炔基取代基,从而为高度希望的转化提供了一种简单,廉价,有效和实用的解决方案.
Doi:10.1021/cs400515W

专利信息

专利号:WO-2007003236-A1
优先权日:2005-06-30
标 题:Process for synthesis of complex 2-deoxy-2-iodo pyranosides of high purity, particularly suitable for manufacturing pharmaceutically pure annamycin
发明人：SZEJA WIESLAW; GRYNKIEWICZ GRZEGORZ; FOKT IZABELA
权利人:ZACLAD BADAWCZO PROD SYNTEX; SZEJA WIESLAW; GRYNKIEWICZ GRZEGORZ; FOKT IZABELA
摘要:The method according to the invention comprises using as glycosyl donors high purity 2- deoxy-2-iodo derivatives of sugars of a defined configuration of C-2 carbon with O-alkyl, S- alkyl, O-aryl, S-aryl, O-heteroaryl, S-heteroaryl, O-acyl, O-silyl, O-N-imido, O-P- (phosphino, phosphono, thiophosphono, selenophosphono) groups at the anomeric position, and subjecting them to a condensation reaction with a compound containing a hydroxyl group or a protected hydroxyl group in the presence of electrophilic reagents, followed by deprotection and isolation of a pharmaceutically pure product. The objective of the present invention is to provide a method for preparing complex glycosides by coupling cyclic multifunctional compounds containing hydroxyl functional groups (glycosyl acceptors, including aglycones of natural origin which are known as constituents of active pharmaceutical ingredients) with diastereoisomerically pure 2-deoxy-2-halopyranosyl derivatives containing anomeric substituent capable of exchange under glycosidating conditions, for example by virtue of activation with electrophilic agents. This method substantially simplifies the synthesis of Annamycin. The present invention relies on a regio- and stereoselective reaction of cohalogenating 1,2- unsaturated sugars in the presence of hydroxyl group containing compounds, such as: water, alcohols, phenols, carboxylic acids, silanols, phosphinic acids, phosphoric acids, thiophosphoric acids, selenophosphoric acids, followed by separation of the product with proper C-2 carbon configuration required for the synthesis. As the separation of stereoisomers is carried out at the stage of obtaining a relatively inexpensive intermediate in the form of glycosyl donor, the method of the invention substantially reduces the cost of Annamycin manufacture. Other advantages of the synthesis process of the invention consist in the reduction of the number of stages of the antibiotic manufacture process and in yield increase of the final product.

专利号:WO-2024008084-A1
优先权日:2022-07-08
标 题 :METHOD FOR CATALYZED SYNTHESIS OF CHIRAL α-AMINOPHOSPHONIC ACID DERIVATIVE WITH CINCHONA ALKALOID DERIVATIVE
发明人：DENG LI; LU JIAXIANG
权利人:UNIV WESTLAKE
摘要:The present invention provides a method for catalyzed synthesis of a chiral α-aminophosphonic acid derivative with a cinchona alkaloid derivative. Particularly, the present invention provides a method for catalyzed synthesis of a chiral α-aminophosphonic acid derivative with a cinchona alkaloid derivative, comprising the following step: obtaining a chiral α-aminophosphonic acid derivative represented by formula III with an imine intermediate represented by formula II under the action of a cinchona alkaloid derivative catalyst.

专利号:US-2017327504-A1
优先权日:2014-10-30
标 题:Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
发明人：ROSE CHRISTOPHER; SILBERGER HERBERT; SCHREINER ERWIN; FELZMANN WOLFGANG; MARAS NENAD
权利人:SANDOZ AG
摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.

专利号:US-4354972-A
优先权日:1981-06-29
标 题 :Synthesis of steroids
发明人：KAISER EMIL T
权利人:KAISER EMIL T
摘要:This invention relates to the synthesis of steroids which are useful for their biological activity or which may be converted to steroids which have such activity. These syntheses include the steroid compounds and processes for their preparation. n An object of the invention is to provide syntheses which are applicable to materials which are readily available in good supply for converting such materials to steroids which are useful and desirable in the manufacture of pharmaceutical products. n More particularly, I have sought to discover processes and intermediate compounds useful in the synthesis of 24, 25-dihydroxycholesterol from hyodeoxycholic acid or lithocholic acid which are constituents of, and readily available from, animal bile.

专利号:US-4841045-A
优先权日:1985-03-12
标 题 :Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.

专利号:US-4897477-A
优先权日:1985-03-12
标题:Synthesis of vinblastine and vincristine type compounds
发明人：KUEHNE MARTIN
权利人:UNIV VERMONT
摘要:A new process for the stereospecific synthesis of alkaloids of the vinblastine and vincristine type including the synthesis of vinblastine and vincristine as well novel alkaloids which are active as anti-tumor agents.