CAS: 24487-91-0; 2-Methyl-3-Methoxybenzoylchloride

上下游产品

CAS号55289-06-0 3-甲氧基-2-甲基苯甲酸 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号72623-17-7 2-(3-methoxy-2-... | CAS号73453-77-7 4,5-DIHYDRO-2-(... | CAS号603-80-5 3-羟基-2-甲基苯甲酸 | CAS号131-27-1 2-萘胺-4,8-二磺酸 | CAS号603-80-5 3-羟基-2-甲基苯甲酸 | CAS号860732-72-5 2,6-dihydroxy-1... | CAS号860731-27-7 2,6-Dimethoxy-1... | CAS号161050-58-4 甲氧虫酰肼 | CAS号740799-69-3 3-甲氧基-2-甲基苯并肼 | CAS号95330-29-3 3-methoxy-N,2-d... | CAS号551964-10-4 N-(2,3-dimethyl... | CAS号644980-59-6 5-(3-methoxy-2-...

2-甲基-3-硝基苯甲酸置于氯化亚砜,硫酸,Palladium On Activated Charcoal,水,氢气,Sodium Hydroxide,Sodium Nitrite体系中,用 甲醇,水,N,N-二甲基甲酰胺,甲苯 用作溶剂,40.0~100.0 °C,500.01 Kpa 条件下,反应 17.5H,反应生成2-甲基-3-甲氧基苯甲酰氯
参考文献:一种2-甲基-3-甲氧基苯甲酰氯的合成工艺
标题:一种2-甲基-3-甲氧基苯甲酰氯的合成工艺
摘要:本发明公开了一种2‑甲基‑3‑甲氧基苯甲酰氯的合成工艺,采用低廉的邻二甲苯为起始原料,通过常规合成方法硝化,酯化,还原,重氮化,甲基化,酰氯化等步骤合成得到产品,总收率控制在65%以上.中间产物酯化步骤提高了中间体可分离程度;重氮步骤加入了反应溶剂,工艺参数较易控制,本步骤中间体纯度在96%以上,为后续产品品质提供了保障,产品品质稳定可靠,成本低廉.

专利信息

专利号:WO-2022222272-A1
优先权日:2021-04-19
标 题 :Synthesis process of 2-methyl-3-methoxybenzoic acid
发明人：GENG JINGKUN; Fang Zheneng; YAO LINXI; JI PINJUN; ZHANG YANCHAO; MIAO JUNHUI; WANG BOTAO
权利人:JIANGSU YONGAN CHEMICAL CO LTD
摘要:Disclosed is a synthesis process of 2-methyl-3-methoxybenzoic acid. The synthesis process comprises the following steps: (1) a reductive hydrogenation reaction, involving: using 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst to prepare 3-amino-2-methylbenzoic acid or methyl 3-amino-2-methylbenzoate by means of hydrogenation reduction; (2) a one-pot reaction of diazotization, hydrolysis and esterification, involving: using the reduction product as a raw material and methanol as a solvent to prepare methyl 3-hydroxy-2-methylbenzoate by means of diazotization, hydrolysis and esterification reactions under the action of a diazotization reagent; (3) a methylation reaction, involving: using methyl 3-hydroxy-2-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent to prepare methyl 3-methoxy-2-methylbenzoate by means of a methylation reaction in the presence of an alkali; and (4) a hydrolysis reaction, involving: mixing methyl 3-methoxy-2-methylbenzoate with an alkali and water, and heating same for hydrolysis, cooling same after the reaction is completed, adjusting the pH to 1-3 with an acid to precipitate a product, followed by filtering and drying same to obtain 3-methoxy-2-methylbenzoic acid.

专利号:WO-9314086-A1
优先权日:1992-01-17
标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists
发明人：FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D
权利人:SYNTEX INC
摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.

专利号:CN-113248351-B
优先权日:2021-05-26
标 题 :Preparation method of 6-chloro-2-methoxytoluene and synthesis technology of methoxyfenozide

专利号:CN-109384667-A
优先权日:2017-08-02
标 题 :A kind of synthesis technique of 2-methyl-3-methoxybenzoyl chloride

专利号:CN-113248351-A
优先权日:2021-05-26
标 题:Preparation method of 6-chloro-2-methoxytoluene and synthesis technology of methoxyfenozide

专利号:CN-113511968-A
优先权日:2021-04-19
标 题 :A kind of synthesis technique of 2-methyl-3-methoxybenzoic acid