CAS: 65-86-1; 2,6-Dioxo-1,2,3,6-Tetrahydropyrimidine-4-Carboxylic Acid

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5-海因乙酸置于manganese(Iv) Oxide,Copper(II) Sulfate,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 29.0H,以10.97%的收率获得产物乳清酸
参考文献:嘧啶核碱基生物合成的非酶类似物
标题:嘧啶核碱基生物合成的非酶类似物
摘要:生命起源的代谢理论认为,无机催化剂使自组织化学前体能够进入代谢途径,包括那些制造遗传分子的化学前体.最近,显示许多核心代谢途径的非酶版本的实验已经开始支持这一想法.然而,沿从头核糖核苷酸生物合成途径的非酶反应序列的实验演示是有限的.在这里,我们展示了将天冬氨酸转化为乳清酸的嘧啶核碱基生物合成的所有三个反应在 60 oc 下进行,无需光化学,在金属(例如 Cu 2+ 和 Mn 4+)存在的情况下,在水性条件下进行.将反应组合成一锅变体也是可能的.生命可能并没有从头开始发明嘧啶核碱基生物合成,而只是简单地改进了现有的非酶反应通道.这项工作是将生命起源的代谢理论与以遗传分子为中心的代谢理论结合起来的第一步.
DOI:10.1002/anie.202117211

专利信息

专利号:US-12162849-B2
优先权日:2018-12-21
标题 :Synthesis of 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or of the methyl-d3 deuterated form thereof
发明人：HOVEYDA HAMID; DUTHEUIL GUILLAUME
权利人:OGEDA SA
摘要:The present invention relates to a method of synthesis of compound (I), wherein R1 represents methyl or methyl-d3, thus corresponding to 3-methyl-1,2,4-thiadiazole-5-carbohydrazide or to the methyl-d3 deuterated form thereof. These compounds are useful as key intermediates in the synthesis of pharmaceutical compounds, especially fezolinetant and deuterated fezolinetant.

专利号:US-2024294464-A1
优先权日:2021-10-27
标题 :Synthesis of restrained complexing agents
发明人：WONG NICHOLAS; GOSSELIN FRANCIS
权利人:GENENTECH INC
摘要:Improved methods of synthesis of a restrained complexing agent are described herein. Compounds, including salts and solvates thereof, and compositions relevant to the improved methods are also described.

专利号:US-10918627-B2
优先权日:2016-05-11
标 题:Convergent and enantioselective total synthesis of Communesin analogs
发明人：MOVASSAGHI MOHAMMAD; LATHROP STEPHEN PAUL; POMPEO MATTHEW W; CHANG WEN-TAU TIMOTHY
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I): n nor a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 -R 8 and m, n, r, s, t, and u are as defined herein, is provided. Methods of making such compounds are also disclosed as are methods for the treatment of cancer, various infectious diseases, and abnormal cardiovascular function.

专利号:WO-2017033128-A1
优先权日:2015-08-25
标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors
发明人：HOOK DAVID; KU JIE; ZHOU JIANGUANG
权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG
摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

专利号:WO-0012747-A1
优先权日:1998-08-31
标 题 :Method for enzymatic synthesis of glycosides, disaccharides, and oligosaccharides
发明人：NILSSON KURT
权利人:NILSSON KURT
摘要:The present invention describes a method for enzymatic synthesis of glucosides, disaccharides, oligosaccharides, modified disaccharides and oligosaccharides, preferably of the kind found in glycoproteins and especially of Lacto-N-tetraose (LNT) and of Lacto-N-neotetraose (LNnT).

专利号:US-7820795-B2
优先权日:2004-03-30
标 题:Lactobacillus fermentum N-desoxyribosyl transferases and the use thereof for enzymatic synthesis of 2′, 3′—didesoxynucleosides and 2′,3′- didehydro-2′,3′- didesoxynucleosides
发明人：KAMINSKI PIERRE-ALEXANDRE
权利人:PASTEUR INSTITUT
摘要:N-deoxyribosyl transferases of Lactobacillus fermentum and their analogues, as well their use for the enzymatic synthesis of 2′,3′-dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides. These transferases and their analogues include a N-deoxyribosyl transferase protein (DTP) that has at least 70%-95% identity with the polypeptide of SEQ ID NO: 2 or SEQ ID NO: 4, that retains residues Y13, D77, D97, E103, and M312 which respectively correspond to positions 13, 77, 97, 103, and 132 of SEQ ID NO: 2; and that has threonine at a position corresponding to position 15 of SEQ ID NO: 2 or SEQ ID NO: 4. Polynucleotides, vectors and host cells encoding these N-deoxyribosyl transferases and their analogues.