4-溴-3-硝基苯甲醛置于sodium Dithionite,水体系中,化学反应生成4-溴-3-氯-苯甲醛 参考文献:Hodgson; Beard,Journal Of The Chemical Society,1927,P. 25 标题:Hodgson; Beard,Journal Of The Chemical Society,1927,P. 25
专利号:US-8853410-B2 优先权日:2009-04-30 标 题:Process for preparing substituted isoxazoline compounds and their precursors 发明人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN 权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE 摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.
参考文献:10.1007/bf02290617 摘要:Rozhkov E, Piskunova I, Gol'd M, Kalvin'sh I. Cyclic hydrazides. Chemistry of Heterocyclic Compounds. 1998 Jan;34(1):77–91. doi: 10.1007/bf02290617.