CAS: 131410-48-5; Gadodiamide

氯化钆,(6S,7S)-7-[(羟基氨基)甲酰基]-6-[(4-苯基-1-哌嗪基)甲酰基]-5-氮杂螺[2.5]辛烷-5-甲酸甲酯置于naoh体系中,用 盐酸,水 用作溶剂,化学反应生成钆双铵
参考文献:用作mri造影剂的gd(dtpa)2−,Gd(bopta)2−和gd(dtpa-Bma)配合物与三亚乙基四胺-六乙酸盐配体之间的交换反应动力学
标题:用作mri造影剂的gd(dtpa)2−,Gd(bopta)2−和gd(dtpa-Bma)配合物与三亚乙基四胺-六乙酸盐配体之间的交换反应动力学
摘要:在6.5-11.0的ph范围内研究了在mri中用作造影剂的gd(dtpa),Gd(bopta)和gd(dtpa-Bma)配合物之间发生的配体交换反应的动力学.通过在0.15 M Nacl中在25oc下测量水质子弛豫率来实现.该反应的速率成正比ttha的浓度,这表明反应发生用的直接攻击为h我ttha (6-我)-(我= 0,1,2和3)上的gd物种3+配合物,通过三元中间体的形成.Ph值从6.5增至9时,中性gd(dtpa-Bma)的交换反应速率增加,因为质子化程度较低的h Ittha (6-I)-物种可以更有效地攻击gd 3+复合物.[gd(dtpa)] 2-和[gd(bopta)] 2-的交换反应速率也从ph 8.5升高到11,但是从6.5升高到8.5,反应速率出乎意料地降低.通过假设一般酸催化的有效性来解释这种减少.当gd 3+解离时,来自h I Ttha (6-I)-物种(i
Doi:10.1021/ic102390P

专利信息

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-2017151351-A1
优先权日:2015-11-28
标 题:Gd-ENCAPSULATED CARBON DOTS AND METHODS OF MAKING AND USING THEREOF
发明人：XIE JIN; CHEN HONGMIN; LI ZIBO
权利人:UNIV GEORGIA
摘要:Gd-encapsulated carbonaceous dots (Gd@C-dots) hold great potential in clinical translation as Ti contrast agent for magnetic resonance imaging. However, current synthetic techniques yield particles with poor size control; hence, time-consuming size selection is often needed to obtain particles of desired sizes. Disclosed is a process whereby mesoporous silica nanoparticles are used as templates for size-controlled synthesis of Gd@C-dots. The disclosed methods involve calcining a mixture comprising a mesoporous silica nanoparticle, a gadolinium-containing compound, and a chelator, thereby forming the nanoparticles of gadolinium within the mesoporous silica nanoparticle; and removing the mesoporous silica nanoparticle from the nanoparticles of gadolinium.

专利号:US-11419953-B2
优先权日:2020-08-11
标 题:Reduced metastable complex macrocyclic contrast agents
发明人：DESLAURIERS RICHARD; MILBOCKER MICHAEL
权利人:INVENTURE LLC
摘要:Gadolinium based contrast agents (GCA) incorporating linear ligand chelation are fundamentally different from GCAs incorporating macrocyclic ligands. The macrocyclic\\GCAs are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. The synthesis of linear GCAs do not form metastable complexes. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species are not regulated and quickly release free Gd3+ ions upon administration into the body. Gadolinium based contrast agents with near zero metastable species content and methods of synthesizing the same are disclosed. Gadolinium based contrast agents with long dissociation time in the body, and low free Gd3+ ion formation are obtained using a synthesis method which departs in novel ways from the traditional free Gd3+-based synthesis methods.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis