CAS: 1447-88-7; 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-6-Methoxy-4H-Chromen-4-One

上下游产品

CAS号90-24-4 花椒素 | CAS号1486-50-6 4-苄氧基苯甲酰氯 | CAS号480-66-0 2',4',6'-三羟基苯乙酮 | CAS号25892-95-9 4'-苄氧基-6'-羟基-2'... | CAS号3602-54-8 2’,4’-二羟基-6’-甲氧基苯乙酮 | CAS号1486-51-7 4-苄氧基苯甲酸 | CAS号25892-94-8 1-(4-(benzyloxy... | CAS号39548-89-5 1-(4-(苄氧基)-2-羟基... | CAS号99-96-7 4-羟基苯甲酸 | CAS号17680-84-1 高车前苷 | CAS号1061-93-4 [2-acetyloxy-4-... | CAS号529-53-3 野黄芩素

野黄芩素置于盐酸,Potassium Carbonate体系中,用 乙醚,二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 用作溶剂,化学反应 13.0H,反应生成高车前素
参考文献:黄cut苷烷基衍生物的合成及其生物学评估,可预防脂质变性,改善神经退行性疾病.
标题:黄cut苷烷基衍生物的合成及其生物学评估,可预防脂质变性,改善神经退行性疾病.
摘要:背景技术外源性抗氧化剂被认为是治疗神经退行性疾病的有前途的治疗方法,因为它们可以预防和/或最小化氧化引起的神经元损害.目的设计并合成了基于黄cut苷(2)的结构上的三系列亲脂性化合物,黄re苷(2)是黄cut苷(1)在体内的一种代谢产物.方法通过检测亚铁盐/抗坏血酸诱导的脂质自氧化产生的2-硫代巴比妥酸反应性物质(tbars)来评估其抗氧化活性,所述脂质存在于大鼠肝细胞的微粒体膜中.用紫外(uv)分光光度计研究了表示为正辛醇和缓冲液之间分配系数的这些化合物的亲脂性.结果该研究表明在c4'-Oh位置被苄基取代的化合物5E表现出强的抗氧化活性和非常好的亲脂性.结论5E可能是预防或减少与神经退行性过程相关的氧化状态的有效候选者.
Doi:10.2174/1573406414666181015143551

专利信息

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-10532991-B2
优先权日:2018-04-18
标题 :Method for preparing hispidulin and its derivatives
发明人：HUANG WEI-JAN; HSU KAI-CHENG; CHIOU LIH-CHU; CHEN LIANG-CHIEH; TSENG HUI-JU; FAN PI-CHUAN
权利人:UNIV TAIPEI MEDICAL
摘要:Provided is a method for preparing hispidulin or a derivative thereof. The method includes selective protection of trihydroxybenzaldehyde, followed by regioselective iodination, selective protection, Stille coupling, Baeyer-Villiger oxidation and basic hydrolysis to obtain a protected intermediate compound. Then, alkylation, Claisen-Schmidt condensation, cyclization and deprotection of the protected intermediate compound are performed to obtain hispidulin or the derivative thereof. The present disclosure provides an efficient method for total synthesis of hispidulin or the derivative thereof with concise reaction steps and high yield.