CAS: 31972-52-8; Boc-Gly-Gly-Oh

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N-(Tert-Butoxycarbonyl)Glycylglycine Benzyl Ester置于sodium Hydroxide体系中,化学反应生成 Boc-甘氨酰甘氨酸
参考文献:新型四肽,Rgdf,介导的肿瘤特异性脂质体阿霉素(dox)制剂
标题:新型四肽,Rgdf,介导的肿瘤特异性脂质体阿霉素(dox)制剂
摘要:精氨酸-甘氨酸-天冬氨酸(rgd)已显示出对在肿瘤细胞中过度表达的整联蛋白具有很强的亲和力,尤其是在肿瘤浸润,血管反应生成和转移过程中.在其他工作的基础上,已设计并研究了一种新颖的四肽精氨酸-甘氨酸-天冬氨酸-苯基苯胺(rgdf)作为将脂质体阿霉素(dox)导向肿瘤细胞的归巢装置.为了将rgdf掺入脂质体dox制剂中,将rgdf与三种不同的脂肪醇偶联,以获得rgdf-脂肪醇偶联物.合成甘氨酸-甘氨酸-天冬氨酸-苯基苯胺(ggdf)-月桂醇缀合物作为阴性对照.rgdf-脂肪醇共轭物(rgdfo(ch 2)n Ch 3)和ggdf-月桂醇共轭物(l-Ggdfc12-Dox)掺入的脂质体制剂,首先使用膜分散法制备脂质体,然后使用跨膜ph梯度法上样dox.由于两亲性质,Rgdf-或ggdf-脂肪醇结合物很容易掺入脂质体,其脂肪烷基链插入脂质体双层脂肪酰基链之间,而亲水肽部分(rgdf或ggdf)锚定在
DOI:10.1021/mp200039S

专利信息

专利号:US-5712367-A
优先权日:1989-10-02
标 题:Process for the solubilization of peptides and process for peptide synthesis
发明人：BERNARD JEAN-MARIE; BOUZID KAMEL; GERVAIS CHRISTIAN
权利人:RHONE POULENC CHIMIE
摘要:A process is disclosed for making peptides soluble in a water-immiscible organic solvent, comprising linking a lipophilic group with an amide or ester bond to the terminal carboxyl group of said peptide; when the lipophilic group is linked to L-serine, a molecule is obtained with a solubility in water at 25 DEG C. of less than 30 g/liter. This lipophilic group is non-polymeric and chemically defined. A process is also disclosed for the synthesis of peptides, optionally protected, in a liquid medium, wherein the starting material is an amino acid or peptide made soluble in an organic medium by a lipophilic group A-L linked to the carboxyl function of the starting amino acid or peptide, and are added to amino acids or peptides to be condensed which are activated on their acid function and protected on their amine function and are optionally protected on their side chain. The peptides resulting from the synthesis are used, where appropriate, for the synthesis of medicinal products, vaccines or agri-foodstuff or plant-protection.

专利号:US-4786684-A
优先权日:1986-08-21
标题 :Benzylthioether-linked solid support-bound thiol compounds and method for peptide synthesis
发明人：GLASS JOHN D
权利人:SINAI SCHOOL MEDICINE
摘要:A method for the synthesis of sulfydryl-containing peptides which comprises forming a benzylthioether-linked solid support-bound thiol compound having at least one functional group for generating at least one peptide bond, sequentially coupling at least one protected amino acid or peptide to the compound until a peptide having desired amino acid sequence is obtained, and cleaving the benzylthioether linkage to release the peptide from the support with concomitant regenertion of the sulfydryl group in the peptides. The invention also encompasses compounds having the general formula wherein X is H, NH2, or acyl-NHY, said acyl being an amino acid or a peptide; Y is H, COOH, CONHNH2, the ester COOR1 in which R1 is selected from the group consisting of methyl, ethyl, phenyl, ortho-nitrophenyl and para-nitrophenyl, the amide CONH2, or the amide CONHR2 in which R2 is an amino acid or peptide; and providing that X and Y cannot both be H.

专利号:US-6713607-B2
优先权日:1994-03-08
标 题:Effector proteins of Rapamycin
发明人：CAGGIANO THOMAS J; CHEN YANQIU; FAILLI AMEDEO A; MOLNAR-KIMBER KATHERINE L; NAKANISHI KOJI
权利人:WYETH CORP; UNIV COLUMBIA
摘要:This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti-restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.

专利号:WO-2025151642-A1
优先权日:2024-01-09
标题 :Modified elongation factor p and methods of use thereof
发明人：HECHT SIDNEY; DEDKOVA LARISA; POTUGANTI GAL REDDY; DASKALOVA SASHA
权利人:UNIV ARIZONA STATE
摘要:Provided herein are modified elongation factor P (EF-P) enzymes capable of incorporating noncanonical amino acids during protein synthesis at efficiencies that are different than those of native EF-P. Also provided are methods for preparing and using modified EF-P enzymes.

专利号:US-2025170267-A1
优先权日:2022-02-28
标 题 :Antibody-drug conjugate precursor and intermediate for synthesis thereof
发明人：TSUZAKI YASUNORI; MIZUNO GEN; KASHIWAGI TAKAMASA; TANAKA MASAYUKI; SHIMIZU HAYATO; NONOUCHI SHIMPEI; MATSUSHITA TAKASHI; KIMURA TOMIO
权利人:UBE CORP
摘要:A method for improving the stability of an antibody-drug conjugate in a living body, and a conjugate precursor for producing a stabilized antibody-drug conjugate. An antibody-drug conjugate precursor represented by the following general formula (I) or a salt thereof, a synthetic intermediate thereof or a salt thereof, n Z-L-D  (I)n n where Z is a reactive group which can react with a functional group present in an antibody or a modified antibody; D is an antitumor drug residue in which one hydrogen atom or one hydroxy group is removed from any position of an antitumor drug molecule or an analog thereof or a derivative thereof; L is a linker which links Z to D; and at least any one of D and L has one or more lactonyl group(s) at any position(s) as substituent(s) or protecting group(s).

专利号:US-2020369716-A1
优先权日:2017-08-01
标 题 :Solid-phase synthesis of protein-polymer conjugates on immobilization supports
发明人：MURATA HIRONOBU; RUSSELL ALAN J
权利人:UNIV CARNEGIE MELLON
摘要:Materials and methods for generating protein-polymer conjugates on solid supports are provided herein. The methods can include, for example, reversibly immobilizing a protein on a solid support, modifying the protein by adding polymer subunits, and releasing the protein-polymer conjugate from the solid support.