CAS: 34941-91-8; 2-Chloro-4-Fluoropyridine

相似化合物

52074-49-4 31301-51-6 1214350-63-6

上下游产品

CAS号23056-36-2 2-氯-4-硝基吡啶 | CAS号1060809-20-2 6-氯-4-氟烟醛 | CAS号944401-77-8 2-氨基-4-氟吡啶 | CAS号71506-83-7 2-氯-4-甲硫基吡啶 | CAS号34415-32-2 2,3,5,6-四氯-4-氟吡啶 | CAS号929022-76-4 2-氯-4-氟烟酸 | CAS号944401-69-8 5-溴-2-氨基-4-氟吡啶

2-氯-4-硝基吡啶置于四丁基氟化铵体系中,用 四氢呋喃,水,N,N-二甲基甲酰胺 用作溶剂,化学反应 0.5H,以53%的收率获得2-氯-4-氟吡啶
参考文献:四丁基铵盐诱导的硝基吡啶的反硝化:氟,羟基和甲氧基吡啶的合成.
标题:四丁基铵盐诱导的硝基吡啶的反硝化:氟,羟基和甲氧基吡啶的合成.
摘要:报道了一种通过氟脱硝反应合成氟吡啶的有效方法.反应在温和的条件下由四丁基氟化铵(tbaf)介导,而无需过多考虑水的存在.对于2-或4-硝基取代的吡啶,通常进行氟脱硝,而3-硝基吡啶需要伴随的吸电子基团以使反应有效地进行.硝基吡啶在相应的四丁基铵物质存在下,在温和的条件下也会进行羟基-和甲氧基的脱硝反应.[反应:看文字]
Doi:10.1021/ol047688V

专利信息

专利号:US-2023399302-A1
优先权日:2020-10-29
标题:Process for the preparation of heteroaryl-substituted sulfur(vi) compounds
发明人：LOPCHUK JUSTIN M; SHULTZ ZACHARY P; SCATTOLIN THOMAS
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of organic compounds, in particular processes for the synthesis of heteroaryl-substituted sulfur(VI) compounds by nucleophilic aromatic substitution.

专利号:US-12304912-B2
优先权日:2020-07-28
标 题 :Fused bicyclic RAF inhibitors and methods for use thereof
发明人：BELFIELD ANDREW; JONES CLIFFORD DAVID; MARGATHE JEAN-FRANÇOIS; COLLETTO CHIARA
权利人:JAZZ PHARMACEUTICALS IRELAND LTD
摘要:The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.

专利号:CN-112409354-A
优先权日:2020-12-23
标题:A kind of synthesis technique of 7-fluoroimidazo[1,2-A]pyridine and its intermediate

专利号:CN-116836111-A
优先权日:2023-09-01
标题 :A kind of continuous synthesis method of fluoropyridine

专利号:CN-112409354-B
优先权日:2020-12-23
标题:Synthesis process of 7-fluoroimidazo [1,2-A ] pyridine and intermediate thereof