CAS: 38573-88-5; 1-Bromo-2,3-Difluorobenzene

上下游产品

1,2-difluoro-3-methyl-benzene 1,1,2,2-tetrafluoro-3-vinylcyclobutane 3,3,4,4-tetrafluor°Cyclohexene 1-(2,3-difluorophenyl)piperazine 4-[4-(2,3-difluorophenyl)piperazin-1-yl]butyronitrile 4-[4-(2,3-difluorophenyl)piperazin-1-yl]butylamine 4-(3-bromo-2-fluorophenoxy)-1-methylpiperidine

2,3-二氟甲苯置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 二氯甲烷 用作溶剂,以91%的收率获得2,3-二氟溴苯
参考文献:一种巴洛沙韦中间体的制备方法
标题:一种巴洛沙韦中间体的制备方法
摘要:本发明公开了一种巴洛沙韦中间体的制备方法,具体涉及以2,3‑二氟甲苯为原料,经溴代反应,取代反应,关环反应三步高效合成7,8‑二氟‑二苯并[b,E]噻吩并‑11(6H)‑酮,本发明提供的7,8‑二氟‑二苯并[b,E]噻吩并‑11(6H)‑酮是一种高收率,低成本,三废少,产品纯度好,适宜工业化的制备方法.

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:US-12172982-B2
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds
发明人：LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

专利号:US-8962858-B2
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
发明人：MITASEV BRANKO; KIM DAE-SHIK; ZHANG HUIMING; FARTHING CHRISTOPHER N
权利人:EISAI R&D MAN CO LTD
摘要:Provided are compounds and methods useful for the preparation of compounds useful as inhibitors of beta-site amyloid precursor protein (APP)-cleaving enzyme.

专利号:US-8802871-B2
优先权日:2011-01-21
标 题:Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives

专利号:CN-108373416-B
优先权日:2018-04-28
标 题 :A kind of method of photo/nickel synergistic catalysis synthesis of diarylamine

专利号:US-2013197244-A1
优先权日:2011-01-21
标题 :Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives