专利号:US-7749985-B2 优先权日:2006-09-15 标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use 发明人:GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE 权利人:XENOPORT INC 摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.
专利号:US-8920675-B2 优先权日:2010-10-27 标题 :Synthesis, capping and dispersion of nanocrystals 发明人:XU WEI; GONEN WILLIAMS ZEHRA SERPIL; WANG YIJUN; WIACEK ROBERT J; BAI XIA; GOU LINFENG; THOMAS SELINA I; XU JUN 权利人:XU WEI; GONEN WILLIAMS ZEHRA SERPIL; WANG YIJUN; WIACEK ROBERT J; BAI XIA; GOU LINFENG; THOMAS SELINA I; XU JUN; PIXELLIGENT TECHNOLOGIES LLC 摘要:Preparation of semiconductor nanocrystals and their dispersions in solvents and other media is described. The nanocrystals described herein have small (1-10 nm) particle size with minimal aggregation and can be synthesized with high yield. The capping agents on the as-synthesized nanocrystals as well as nanocrystals which have undergone cap exchange reactions result in the formation of stable suspensions in polar and nonpolar solvents which may then result in the formation of high quality nanocomposite films.
专利号:US-2008146526-A1 优先权日:2006-09-15 标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:US-2009286759-A1 优先权日:2006-09-15 标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
专利号:US-2015203989-A1 优先权日:2010-04-23 标题:Synthesis, capping and dispersion of nanocrystals
专利号:WO-2008033572-A1 优先权日:2006-09-15 标题:Acyloxyalkyl carbamate prodrugs, methods of synthesis and use