专利号:US-2024182421-A1 优先权日:2021-03-19 标题 :Synthesis of endochin-like quinolones 发明人:RISCOE MICHAEL K; NILSEN AARON; JIN HAIHONG; POU SOVITJ; WINTER ROLF W; DODEAN ROZALIA ANA; LIEBMAN KATHERINE M 权利人:UNIV OREGON HEALTH & SCIENCE; US GOV VETERANS AFFAIRS 摘要:Described herein are new synthetic routes for production of Endochin-Like Quinolone (ELQ) compounds. Synthetic routes to 3-substituted 4(1H)-quinolones are presented that are amenable to industrial scale preparation. One herein presented approach is relatively short, does not require palladium, and involves no chromatographic separation. A second herein presented approach is similarly relatively short, does not require palladium, involves no chromatographic separation, and also avoids high vacuum distillation. Additionally, both approaches require no protecting group chemistry because the insoluble 4(1H)-quinolone is not formed until the final reaction step.
专利号:CN-110204558-B 优先权日:2014-08-15 标 题:Synthesis of cephalosporin compounds
专利号:WO-2022197979-A1 优先权日:2021-03-19 标题:Synthesis of endochin-like quinolones
专利号:EP-4308109-A1 优先权日:2021-03-19 标 题:Synthesis of endochin-like quinolones
专利号:CN-117042768-A 优先权日:2021-03-19 标题:Synthesis of doxine-like quinolones
专利号:WO-2024101431-A1 优先权日:2022-11-10 标 题:Method for synthesizing peptide 发明人:YANO SHINYA 权利人:SEKISUI MEDICAL CO LTD 摘要:The purpose of the present invention is to provide a method for synthesizing a peptide or a long-chain peptide that uses amino acids including an amino acid containing a certain number of hydrophobic amino acids and an amino acid with a functional group on a side chain, the method not including the addition of additional solvents and not reducing the efficiency of Fmoc amino acid condensation reactions or Fmoc removal reactions. Provided is a method for synthesizing a peptide, the peptide containing one or more amino acids with a functional group on a side chain, 50% or more of a hydrophobic amino acid, and 10% or less of an amino acid in which an α amino group is a secondary amino group; or a peptide with 21 or more residues and containing one or more amino acids with a functional group on a side chain. The method comprises introducing a carrier for peptide synthesis expressed by the general formula (1) below into the side chain of the amino acid with the functional group on a side chain.
1: Zaafan MA, Zaki HF, El-Brairy AI, Kenawy SA. Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters. Exp Lung Res. 2016 Oct 31:1-9. [Epub ahead of print] doi: 10.1016/j.aca.2015.06.021. doi: 10.1039/c1dt11475a. doi: 10.1016/j.transproceed.2010.12.053. Chinese. 11: Malaguarnera L, Pilastro MR, Vicari L, Dimarco R, Manzella L, Palumbo G, Messina A. Pyrrolidinedithiocarbamate induces apoptosis in human acute myelogenous leukemic cells affecting NF-kappaB activity. Cancer Invest. 2005;23(5):404-12.
合成参考文献
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 摘要:Ho, C.-Y.; Raja, D., Science of Synthesis: Knowledge Updates, (2023) 1, 47. 参考文献:10.1007/s00216-002-1326-7 摘要:Giokas DL, Paleologos EK, Karayannis MI. Speciation of Fe(II) and Fe(III) by the modified ferrozine method, FIA–spectrophotometry, and flame AAS after cloud-point extraction. Analytical and Bioanalytical Chemistry. 2002 Jul;373(4-5):237–43. doi: 10.1007/s00216-002-1326-7.