CAS: 54024-22-5; Desogestrel

上下游产品

CAS号54024-21-4 13-乙基-11-亚甲基-4-... | CAS号74-86-2 乙炔 | CAS号220332-82-1 (17BETA)-13-乙基-... | CAS号161640-05-7 17β-(tert-butyl... | CAS号54048-10-1 依托孕烯

(8'S,9'S,10'R,13'S,14'S,17'R)-13'-Ethyl-17'-Ethynyl-11'-Methylidenespiro[1,3-Dithiolane-2,3'-2,6,7,8,9,10,12,14,15,16-Decahydro-1H-Cyclopenta[a]Phenanthrene]-17'-Ol置于sodium体系中,用 四氢呋喃,氨 作为反应溶剂,化学反应 1.0H,以58%的收率获得产物去氧孕烯
参考文献:基于11β-羟基-19-降糖甾体分子内氧化为13-乙基-11-亚甲基-18,19-Dinor-17α-Pregn-4-En-20-Yn-17-Ol(去氧孕烯)的部分合成1811β-内酯
标题:基于11β-羟基-19-降糖甾体分子内氧化为13-乙基-11-亚甲基-18,19-Dinor-17α-Pregn-4-En-20-Yn-17-Ol(去氧孕烯)的部分合成1811β-内酯
摘要:据报道13-乙基-18-降糖甾烷去氧孕烯的部分合成.该合成过程中的关键步骤是将11β-羟基estr-5-Ene-3,17-二酮环状双-(1,2-乙二缩醛)3与pb(oac)4和碘分子内氧化为3,3:17,17-双[1,2-乙二基双(氧基)]-11β-羟基estr-5-En-18-油酸γ-内酯2.
DOI:10.1002/recl.19881070406

专利信息

专利号:US-9422326-B2
优先权日:2012-09-04
标 题:Process for preparing 11-methylene-18-methyl-estr-4-en-3, 17-dione, useful as intermediate compound for the synthesis of molecules having pharmacological activity
发明人：LENNA ROBERTO; MARIANI EDOARDO; VANOSSI ANDREA
权利人:IND CHIMICA SRL
摘要:There is described a process for the industrial synthesis of 11-methylene-18-methyl-estr-4-en-3,17-dione, a compound having the structure formula (I) depicted below: (Formula I) (I) useful as intermediate compound in the synthesis of the progestin compounds Desogestrel and Etonogestrel.

专利号:WO-2009033499-A1
优先权日:2007-09-13
标 题 :Total synthesis of enantiopure desogestrel
发明人：TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE
权利人:UNIV GOETTINGEN GEORG AUGUST; TIETZE LUTZ FRIEDJAHN; KRIMMELBEIN IIGA KRISTINE
摘要:The present invention relates to a total synthesis of desogestrel and derivatives thereof, and to intermediate compounds of this synthesis.

专利号:US-9464108-B2
优先权日:2012-03-15
标 题:Combined synthesis route for desogestrel and etonogestrel
发明人：OSTENDORF MARTIN
权利人:MSD OSS BV; MERCK SHARP & DOHME
摘要:The present invention relates to a synthesis route and to steroid derivatives of general formula VI and VII useful in the synthesis of desogestrel and etonogestrel.

专利号:US-5831104-A
优先权日:1993-09-10
标 题:Steroid intermediate products and method of their production
发明人：RING SVEN; TEICHMUELLER GERHARD; WEBER GISELA; SCHWARZ SIGFRID; ERHART BERND; UNDEUTSCH BERND; RAETHE HARALD; MOELLMANN PETER; PFEIFFER CARMEN; PALME HANS-JOACHIM
权利人:JENAPHARM GMBH
摘要:The invention is directed to novel steroid intermediate products of general formula I ##STR1## The steroid intermediate products which can be isolated according to the invention are suitable for the synthesis of 13-ethyl-11-methylene-18,19-bisnor-17α-pregn-4-en-20-in-17-ol (desogestrel). n Further, processes for producing the steroid intermediate products of general formula I are described. The olefination of the 11-oxo steroids is carried out under the influence of ultrasound.

专利号:US-2013123523-A1
优先权日:2011-11-10
标 题:Methods for the preparation of etonogestrel and desogestrel
发明人：NICKISCH KLAUS; SANTHAMMA BINDU
权利人:NICKISCH KLAUS; SANTHAMMA BINDU
摘要:Described herein is a process for the synthesis of etonogestrel and desogestrel and intermediates used to form etonogestrel and desogestrel.

专利号:US-7667056-B2
优先权日:2002-08-02
标 题 :Process and new intermediates for the preparation of steroids with a progestogen activity
发明人：GRISENTI PARIDE; PECORA FABIO; VERZA ELISA; LEONI MASSIMO; BOSSI LAURA
权利人:POLI IND CHIMICA SPA
摘要:The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).