CAS: 56490-94-9; 1-(4-Methoxyphenyl)-2-Methylpropan-2-Amine

上下游产品

N-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl]-formamideN-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl]-formamide 2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl is°Cyanate -1,1-dimethyl-2-(4-methoxyphenyl)ethane1--1,1-dimethyl-2-(4-methoxyphenyl)ethane 4-Methoxy-(2-methyl-2-nitropropyl)benzol N-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl]-glycine nitrileN-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl]-glycine nitrile 2-{(S)-2-Hydroxy-3-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamino]-propoxy}-nicotinonitrile 2-{2-Hydroxy-3-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamino]-propoxy}-nicotinonitrile 2-Hydroxy-5-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamino]-ethyl}-benzoic acid methyl ester

对羟基苯甲醇置于potassium Fluoride,四丁基氯化铵,镍 Sodium Hydroxide,四丁基氢氧化铵,氢气体系中,用 甲醇,二氯甲烷 作为反应溶剂,100.0 °C,15.2 Mpa 条件下,反应 40.17H,反应生成 1-(4-甲氧基苯基)-2-甲基丙烷-2-胺
参考文献:4-(2-氨基-2-甲基丙基)苯酚通过氟离子催化的 4-羟基苯甲醇与 2-硝基丙烷缩合
标题:4-(2-氨基-2-甲基丙基)苯酚通过氟离子催化的 4-羟基苯甲醇与 2-硝基丙烷缩合
摘要:4-羟基苄醇1可在氟离子催化下与2-硝基丙烷缩合得到4-(2-甲基-2-硝基丙基)酚2.酚羟基的甲基化产生甲基醚 7.催化氢化产生来自 2 和 7 的胺 8,可用作合成 β-拟交感神经活性化合物的结构单元.
DOI:10.1002/ardp.19833160303

专利信息

专利号:US-7902394-B2
优先权日:2006-12-18
标题:Calcilytic compounds
发明人：MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT
权利人:GLAXOSMITHKLINE LLC
摘要:Novel calcilytic compounds of Formula (I), pharmaceutical compositions, methods of synthesis, and methods of using them are provided.