CAS: 7206-70-4; 4-Amino-5-Chloro-2-Methoxybenzoic Acid

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CAS号4093-31-6 5-氯-4-乙酰氨基-2-甲氧... | CAS号24201-13-6 2-甲氧基-4-乙酰胺基-5-氯-苯甲酸 | CAS号20896-27-9 4-氨基-5-氯-2-甲氧基苯甲酸甲酯 | CAS号27492-84-8 2-甲氧基-4-氨基苯甲酸甲酯 | CAS号4093-29-2 胃复安甲基物 | CAS号4093-28-1 4-乙酰氨基水杨酸甲酯 | CAS号65-49-6 对氨基水杨酸 | CAS号4136-97-4 2-羟基-4-氨基苯甲酸甲酯 | CAS号364-62-5 甲氧氯普胺 | CAS号4093-31-6 5-氯-4-乙酰氨基-2-甲氧... | CAS号148868-55-7 2-piperidin-1-y... | CAS号14401-36-6 4-amino-5-chlor... | CAS号199479-30-6 4-amino-5-chlor... | CAS号22459-75-2 5-chloro-N-[2-(... | CAS号20896-27-9 4-氨基-5-氯-2-甲氧基苯甲酸甲酯 | CAS号27260-19-1 N-Desethyl Meto... | CAS号98446-49-2 2,4-二氯-5-甲氧基苯胺 | CAS号81098-60-4 西沙必利

4-氨基水杨酸置于n-氯代丁二酰亚胺,硫酸,溶剂黄146,Sodium Hydroxide体系中,用 乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 3.0H,反应生成 4-氨基-5-氯-2-甲氧基苯甲酸
参考文献:Synthesis And Biological Evaluation Of Berberine Derivatives As Ibs Modulator
标题:Synthesis And Biological Evaluation Of Berberine Derivatives As Ibs Modulator
摘要:肠易激综合征是最常见的功能性胃肠道疾病,其特点是慢性腹痛或不适,并伴有排便习惯的改变.5-Ht 受体调节剂已被开发为肠易激综合征的治疗药物,并被证明能有效治疗该疾病.在这封信中,我们设计并合成了 12 种小檗碱衍生物作为 5-Ht 受体调节剂.初步生物测试表明,这些新化合物在治疗肠易激综合征方面具有非常好的活性.
DOI:10.2174/157018012800389386

专利信息

专利号:US-6218542-B1
优先权日:1996-10-15
标 题:Synthesis of cisapride
发明人：DE KNAEP ALFONS GASTON MARIA; MOENS LUC JOZEF RAPHAEL; REY MAX
权利人:JENSSEN PHARMACEUTICA, N V
摘要:A new Process of preparing cisapride, and the pharmaceutically acceptable acid addition salts thereof, by reductively aminating 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinone in the presence of benzylamine under hydrogen in a reaction-inert solvent, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of about 93/7, which is enriched in the amount of cis-stereoisomer by converting it into its acid addition salt, by treatment with a suitable inorganic acid, in an appropriate solvent, subsequent crystallisation and conversion to its free base form by treatment with an appropriate base, yielding 1-[3-(4-fluorophenoxy)-propyl]-3-methoxy-4-piperidinamine having a cis/trans ratio of equal to or higher than 98/2.

专利号:RU-2008112215-A
优先权日:2005-08-31
标 题 :METHODS OF SYNTHESIS AND INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF STEREOISOMERIC COMPOUNDS SUITABLE FOR TREATMENT OF GASTROINTESTINAL DISORDERS AND DISORDERS OF THE CENTRAL NERVOUS SYSTEM

专利号:RU-2418798-C2
优先权日:2005-08-31
标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders

专利号:US-7189852-B2
优先权日:2003-09-09
标题 :Synthesis
发明人：PALMER RICHARD MICHAEL JOHN; MEYERS NICHOLAS LESLIE; KNIGHT JOHN
权利人:ALIZYME THERAPEUTICS LTD
摘要:The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.

专利号:US-2025259704-A1
优先权日:2022-06-24
标 题:Systems and methods for cell-free iterative site saturation mutagenesis and its application for the directed evolution of enzymes catalyzing unnatural reactions
发明人：JEWETT MICAHEL C; BOGART JONATHAN W; LANDWEHR GRANT M; Karim Ashty Stephen
权利人:UNIV NORTHWESTERN
摘要:Disclosed are methods, compositions, systems, and protein compounds for the directed evolution of enzymes and proteins. The method comprising generating variant protein with a desired functionality, comprising one or more DNA expression templates comprising nucleic acid sequences encoding a variant protein, expressing the variant protein using cell-free protein synthesis; and analyzing one or more parameters associated with the variant protein.

专利号:US-7427260-B2
优先权日:2001-03-30
标 题:Efficient methods for solid phase synthesis using trityl chloride resins
发明人：PANG YUAN-PING; PARK JEWN GIEW
权利人:MAYO FOUNDATION
摘要:Disclosed are efficient methods for loading amino derivatives onto trityl chloride resins and for cleaving chemically modified amino derivatives from trityl chloride resins. Methods for making a library of discrete chemically modified amino derivatives also disclosed.