CAS: 863329-66-2; 1-((2R,3R,4R,5R)-3-Fluoro-4-Hydroxy-5-(Hydroxymethyl)-3-Methyltetrahydrofuran-2-yl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

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上下游产品

CAS号817204-32-3 (2'R)-N-苯甲酰基-2'... | CAS号1064684-44-1 索罗布维 | CAS号1190307-88-0 索非布韦

4-氨基-1-((2R,3R,4R,5R)-3-氟-4-羟基-5-(羟基甲基)-3-甲基四氢呋喃-2-基)嘧啶-2(1H)-酮置于吡啶,甲醇,氨,溶剂黄146体系中,用 水 作为反应溶剂,化学反应 1.67H,反应生成 (2'R)-2'-脱氧-2'-氟-2'-甲基脲苷
参考文献:Nucleoside Phosphoramidate Prodrugs
标题:Nucleoside Phosphoramidate Prodrugs
摘要:本文披露了用于治疗哺乳动物病毒感染的核苷类衍生物的磷酰胺酯前药,该前药是一种化合物,其立体异构体,盐(酸性或碱性加合盐),水合物,溶剂合物或结晶形式,由以下结构表示:同时还披露了治疗方法,用途和制备过程,每种方法均利用由式i表示的化合物.

专利信息

专利号:US-2017218006-A1
优先权日:2014-07-31
标题 :Synthesis of Phosphoramidates
发明人：WILHELM THORSTEN; SPITZENSTÄTTER HANS-PETER; SCHÖNE OLGA; RICHTER FRANK; SCHREINER ERWIN
权利人:SANDOZ AG
摘要:A process for the preparation of a compound of formula (I) including all isomers, stereoisomers, enantiomers and diastereomers thereof (I), and salts thereof; the process comprising providing a mixture comprising a compound of formula (II) and a compound of formula (III) subjecting the mixture provided in a) to reaction conditions in the presence of one or more Lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (I).

专利号:US-2018162896-A1
优先权日:2015-05-26
标题 :Synthesis of Phosphoramidates
发明人：WILHELM THORSTEN; SCHÖNE OLGA; SPITZENSTÄTTER HANS-PETER
权利人:SANDOZ AG
摘要:A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.

专利号:EP-3174892-A1
优先权日:2014-07-31
标 题:Synthesis of phosphoramidates

专利号:US-2014309413-A1
优先权日:2013-03-11
标题 :Methods of stereoselective synthesis of substituted nucleoside analogs
发明人：ROSE PETER JAMISON; JUNG YOUNG CHUN; BLIGH CAVAN MCKEON; IBRAHIM SHEREEN; ANZALONE LUIGI; MILLER JR DAVID B; VAN ALSTEN JOHN GREGG; CURRAN TIMOTHY THOMAS
权利人:VERTEX PHARMA
摘要:The present invention relates to the novel diastereoselective syntheses for generating phosphorothioate compounds. Examples include nucleoside phosphorothioate analogs that are useful in treating diseases and/or conditions such as viral infections.

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:CA-2954940-A1
优先权日:2014-07-31
标 题 :Synthesis of phosphoramidates