CAS: 100367-77-9; Ethyl 2-Bromothiazole-4-Carboxylate

相似化合物

5198-80-1 5198-88-9 5198-86-7

上下游产品

Ethyl 2-Hydroxythiazole-4-Carboxylate 56417-52-8
2-氨基噻唑-4-甲酸乙酯 2-Aminothiazole-4-Carboxylate 5398-36-7

Ethyl 2-Amino-1,3-Thiazole-4-Carboxylate Hydrobromide置于亚硝酸特丁酯,Copper(Ll) Bromide体系中,用 乙腈 用作溶剂,化学反应 2.5H,反应生成2-溴噻唑-4-甲酸乙酯
参考文献:Viral Polymerase Inhibitors
标题:Viral Polymerase Inhibitors
摘要:公式i所代表的化合物的异构体,对映体,非对映异构体或互变异构体,其中r1选自:H,卤代烷基,(C1-6)烷基,(C2-6)烯基,(C3-7)环烷基,(C2-6)炔基,(C5-7)环烯基,6或10元芳基,Het均可选择性地取代;R2选自(C1-6)烷基,(C3-7)环烷基,(C6-10)双环烷基,6-或10元芳基,或het均可选择性地取代;B为n或cr5,其中r5为h,卤素,卤代烷基,(C1-6)烷基,(C3-7)环烷基或(C1-6)烷基-(C3-7)环烷基;X为n或cr5;D为n或cr5;Y1和y2中的每一个独立地为o或s;Z为o,N或nrz,其中rz为h,(C1-6)烷基,(C3-7)环烷基或(C1-6)烷基-(C3-7)环烷基;R3和r4各自独立地为h,(C1-6)烷基,第一(C3-7)环烷基或6-或10元芳基,Het(C1-6)烷基-6-或10元芳基,(C1-6)烷基-Het;或每个r3和r4独立地共价结合在一起形成第二(C3-7)环烷基,或杂环,均可选择性地取代;或当z为n时,R3或r4中的任一者独立地与之共价结合形成含氮杂环;R7为h,(C1-6烷基),(C3-7)环烷基或(C1-6)烷基-(C3-7)环烷基;或r7与r3或r4中的任一者共价结合形成杂环;A为(C1-6)烷基-Conhr8,其中r8为6-或10元芳基,或het;或a为6-或10元芳基,或het所述芳基或het可选择性地取代;或其盐或衍生物;这类化合物是hcv Ns5B聚合酶的有效抑制剂.

专利信息

专利号:US-2010047841-A1
优先权日:2007-02-27
标 题 :Synthesis of desacetoxytubulysin h and analogs thereof
发明人：WIPF PETER; WANG ZHIYONG
权利人:UNIV PITTSBURGH
摘要:Compounds of formula I, XVI and XXI possess potent cell growth inhibitory activity. These compounds are described have therapeutic utility, particularly in the treatment of cancer as well as conditions and disorders related to uncontrolled cell growth: n n n n n n n n n n wherein the variables R 1 , R 2 , R 3 , R 4 , R 5 , X, Y and Z are described herein.

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds

专利号:US-2009291955-A1
优先权日:2005-11-15
标题 :Azacyclohexane Derivatives as Inhibitors of Stearoyl-Coenzyme a Delta-9 Desaturase
发明人：CRANE SHELDON N; ROBICHAUD JOEL STEPHANE; LEGER SERGE; RAMTOHUL YEEMAN K
权利人:CRANE SHELDON N; ROBICHAUD JOEL STEPHANE; LEGER SERGE; RAMTOHUL YEEMAN K
摘要:Azacyclohexane derivatives of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:WO-2008106080-A9
优先权日:2007-02-27
标题 :Synthesis of desacetoxytubulysin h and analogs thereof

专利号:WO-2008106080-A2
优先权日:2007-02-27
标 题 :Synthesis of desacetoxytubulysin h and analogs thereof

专利号:US-2008139558-A1
优先权日:2006-02-24
标题 :Quinolones useful as inducible nitric oxide synthase inhibitors
发明人：SMITH NICHOLAS D; ROPPE JEFFREY R; BONNEFOUS CELINE; PAYNE JOSEPH E; ZHUANG HUI; CHEN XIAOHONG; LINDSTROM ANDREW K; DURON SERGIO G; HASSIG CHRISTIAN A; NOBLE STEWART A
权利人:KALYPSYS INC
摘要:The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.