CAS: 24016-03-3; 2-Amino-3-Benzyloxypyridine

相似化合物

96166-00-6 754230-78-9 107229-58-3

上下游产品

CAS号16867-03-1 2-氨基-3-羟基吡啶 | CAS号100-44-7 氯化苄 | CAS号39903-01-0 2-羟基-3-氨基-5-溴吡啶 | CAS号260273-82-3 3-(2-氯乙基)-9-羟基-... | CAS号96428-16-9 8-苄氧基-咪唑并[1,2-a]吡啶 | CAS号754230-78-9 2-氨基-5-溴-3-苄氧基吡啶 | CAS号69214-22-8 咪唑并[1,2-a]吡啶-8-醇 | CAS号1008796-22-2 9-(苄氧基)-3-(2-羟基... | CAS号1189516-65-1 帕潘立酮棕榈酸酯氧化杂质 | CAS号144598-75-4 9－羟基利培酮 | CAS号16867-03-1 2-氨基-3-羟基吡啶 | CAS号130049-85-3 (R)-9-Hydroxy R...

2-氨基-3-羟基吡啶 反应生成2-氨基-3-苄氧基吡啶
参考文献:新型杂环酚的合成:8-羟基咪唑并[1,2-A]吡啶
标题:新型杂环酚的合成:8-羟基咪唑并[1,2-A]吡啶
摘要:未知标题化合物的制备已经通过2-氨基-3-羟基吡啶与氯乙醛的缩合而实现.与系列中通常使用的在咪唑基团上发生亲电取代的相关醚的行为形成鲜明对比的是,游离酚羟基的活化使吡啶环优先进行硝化.
Doi:10.1016/s0040-4039(00)98839-7

专利信息

专利号:US-7977480-B2
优先权日:2007-12-10
标 题:Synthesis of paliperidone
发明人：BARTL JIRI; KRAJCOVIC JOZEF; BENOVSKY PETR
权利人:SYNTHON BV
摘要:A 9-hydroxy or 9-acyloxy group can be added to a pyridopyrimidinone ring structure by a process comprising acylating a compound of formula (5) under Vilsmeier-Haack or Friedel-Crafts conditions to form a compound (6); and transforming with a peroxo-compound to obtain the compound (1). n nR represents hydrogen or a C1-C20 acyl group. The process is useful in the synthesis of paliperidone and derivatives.

专利号:US-2008214809-A1
优先权日:2006-08-23
标 题 :Process for the synthesis of CMHTP and intermediates thereof
发明人：DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI; PILARSKY GIDEON
权利人:DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI; PILARSKY GIDEON
摘要:The present invention provides processes of preparing 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone, wherein the processes use 3-(2-chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMBP) and/or 3-(2-chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) having phosphorus at least partially removed as the intermediate.

专利号:US-7820816-B2
优先权日:2006-08-23
标题:Process for the synthesis of CMHTP and intermediates thereof
发明人：DOLITZKY BEN-ZION; SHAPIRO EVGENY; INI SANTIAGO; SHMUELY YARON; LANCRY ELI
权利人:TEVA PHARMA
摘要:The present invention provides 3-benzyloxy-2-aminopyridine (BOPA), 3-(2-Hydroxyethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (HMBP), 3-(2-Chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[1,2-a]pyrimidine-4-one (CMHP) and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone. The present invention also provides processes for preparing these intermediates and for preparing paliperidone.

专利号:US-11667666-B2
优先权日:2020-01-20
标题 :Methods and compositions for treatment of cancer
发明人：SINGHAL ANUJ
权利人:CFD RES CORPORATION
摘要:In an aspect, the disclosure pertains to inhibitors of ANGPTL4; synthesis methods for making disclosed compounds; pharmaceutical compositions comprising disclosed compounds; methods of treating disorders of uncontrolled cellular proliferation, e.g., a cancer; and methods of treating a disease associated with an ANGPTL4 dysfunction using disclosed compounds and pharmaceutical compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:WO-2009074333-A1
优先权日:2007-12-10
标 题 :Synthesis of paliperidone