专利号:US-9611206-B2 优先权日:2011-03-02 标题:Synthesis of intermediate for treprostinil production 发明人:SHARMA VIJAY 权利人:UNITED THERAPEUTICS CORP 摘要:The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound.
专利号:US-2017197898-A1 优先权日:2011-03-02 标 题 :Synthesis of intermediate for treprostinil production
专利号:US-2019233362-A1 优先权日:2014-10-20 标题 :Synthesis of intermediates for producing prostacyclin derivatives
专利号:US-2025002442-A1 优先权日:2014-10-20 标题:Synthesis of intermediates for producing prostacyclin derivatives
专利号:US-10774027-B2 优先权日:2014-10-20 标 题:Synthesis of intermediates for producing prostacyclin derivatives
专利号:EP-3103803-B1 优先权日:2008-10-27 标 题 :Intermediates for the synthesis of mtor kinase inhibitors
1: Clarke M, Ataya A, Turkin AM, Parikh R, Davis K, Miller CE, Kantorovich A, Winkler T, Cassady SJ. Transitioning Between Treprostinil Formulations: Evidence and Strategies. Adv Ther. 2026 Jan;43(1):20-48. doi: 10.1007/s12325-025-03401-6. Epub 2025 Nov 10. 2: Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE. Off-label use of treprostinil in adult patients in clinical cases. World J Clin Cases. 2025 Aug 16;13(23):107279. doi: 10.12998/wjcc.v13.i23.107279. 3: Keeley JH, Skarre J, Reed L, Johnson LA, Falardeau C, Davis BNJ, Das M, Castillo H, McDevitt S. Practical Considerations for Managing Patients on Tyvaso DPI (Treprostinil Inhalation Powder). Pulm Circ. 2025 Jul 3;15(3):e70119. doi: 10.1002/pul2.70119.
合成参考文献
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