CAS: 2942-59-8; 2-Chloronicotinic Acid

相似化合物

1452-94-4 36404-88-3 6602-54-6

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CAS号6602-54-6 2-氯烟腈 | CAS号609-71-2 2-羟基烟酸 | CAS号59-67-6 烟酸 | CAS号49609-84-9 2-氯-3-吡啶羧酸 | CAS号2398-81-4 氧烟酸 | CAS号10026-13-8 五氯化磷 | CAS号1452-94-4 2-氯烟酸乙酯 | CAS号96440-05-0 2-氯-3-乙基吡啶 | CAS号62969-86-2 3-乙基吡啶-2-醇 | CAS号104813-92-5 2-(1-哌嗪)-3-吡啶羧酸甲酯 | CAS号112022-09-0 N-[2-(dimethyla... | CAS号106531-35-5 5H-吡啶并[3,2:5,6]... | CAS号35620-71-4 2-苯氧基烟酸 | CAS号32399-12-5 2-甲胺基-3-吡啶甲醇 | CAS号337958-60-8 5,7-二氯-1,6-萘啶 | CAS号33522-80-4 2-(苄基氨基)烟酸 | CAS号36701-89-0 2-(3-(三氟甲基)苯氧基)烟酸 | CAS号77616-34-3 2(3-trifluorome... | CAS号36404-88-3 2-氯-3-吡啶甲醛

2-Chloro-3-Tert-Butylpyridine置于zinc Diacetate,臭氧体系中,用 乙腈 用作溶剂,以85%的收率获得2-氯烟酸
参考文献:一种一步氧化合成2-氯烟酸的方法
标题:一种一步氧化合成2-氯烟酸的方法
摘要:本发明涉及一种一步氧化合成2-氯烟酸的方法,属于化学合成领域,该方法采用2-氯-3-烷基吡啶或者2-氯-3-烯烃基吡啶为起始原料,以醋酸盐作为催化剂,通入臭氧发生器产生的臭氧,在反应温度为20~100oc条件下得到产物2-氯烟酸.本发明所用的原料简单易得,成本低廉,工艺简单,污染少,符合绿色化学的发展要求.

专利信息

专利号:US-8686157-B2
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof
发明人：SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN
权利人:SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN; VERTEX PHARMA
摘要:The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.

专利号:US-3933830-A
优先权日:1974-09-10
标 题 :Process for the synthesis of 4-(2-pyridylamido ethyl) piperidines
发明人：BARTH WAYNE E; KUHLA DONALD E
权利人:PFIZER
摘要:Disclosed herein is an improved process for the preparation of known hypoglycemic piperidinesulfamylureas of the structure ##EQU1## wherein R is selected from the group consisting of 3-(2-methoxy)pyridyl, 3-(2-ethoxy)pyridyl and 2-(4-chloro)pyridyl and R' is selected from the group consisting of bicyclo[2.2.1]hept-5-en-2-yl-endo-methyl, bicyclo[2.2.1]hept-2-yl-endo-methyl, 7-oxabicyclo[2.2.1]hept-2-yl-methyl, 1-adamantyl and cycloalkyl having from five to eight carbon atoms. n Said process comprises contacting 4-(2-pyridyl-amidoethyl) piperidine of the structure ##EQU2## with substantially one equivalent of sulfamide thereby exclusively sulfonating the piperidine nitrogen atom. Said 4-(2-pyridylamidoethyl)piperidines from the corresponding 4-(2-pyridylamidoethyl) pyridines by selectively activating the more basic nitrogen atom of said pyridine compound either by N-alkylation or by contact with acid and then exclusively reducing the activated pyridine ring with either hydrogen alone or in combination with a metal hydride. Said 4-(2-pyridylamidoethyl)pyridines are produced by contacting 4-(2-aminoethyl)pyridine with a pyridyl acid chloride of the formula R(C=O)Cl. The piperidine sulfonamides produced by the process of the instant invention are converted to the desired hypoglycemic agent by methods well-known to those skilled in the art. n The 4-(2-pyridylamidoethyl)pyridines and piperidines of the instant invention are themselves novel compounds useful as intermediates in the synthesis of piperidine sulfamylurea hypoglycemic agents.

专利号:US-9481649-B2
优先权日:2009-08-24
标题 :Synthesis of a neurostimulative piperazine
发明人：VENKATRAMAN SRIPATHY; MAHMOOD SYED; MOBELE BINGIDIMI I; LAPINA OLGA; VERCOE KELLIE; LI YING; SALSBURY JONATHAN; MCLAWS MARK
权利人:NEURALSTEM INC
摘要:The invention describes an improved synthesis for piperazine derivatized with nicotinic acid and a benzyl moiety. The product compounds are useful for treatment of neurological conditions.

专利号:WO-2016118586-A1
优先权日:2015-01-20
标 题 :Lowcost, high yield synthesis of nevirapine
发明人：AHMAD SAEED; GUPTON FRANK; VERGHESES JENSON; MCQUADE TYLER
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Improved methods of producing the HIV drug substance, nevirapine are provided. The methods employ a cost effective and high yield synthetic methods for preparing the nevirapine building block 2-chloro-3-amino-4-picoline (CAPIC) and 2-cyclopropyl amino nicotinate (Me-CAN), and improvements in other steps of nevirapine synthesis.

专利号:US-2023202980-A1
优先权日:2019-08-30
标题:N-(2-Aminophenyl)-Prop-2-Enamide Derivatives, and Uses Thereof in the Treatment of Cancer
发明人：RADHAKRISHNAN SRIDHAR; TENEN DANIEL G; LIU BEE HUI; VU LE KIM ANH; GO MEI LIN; CHAI LI; GAO CHONG; KAMAL AHMED; SUNKARI SATISH; AYINAMPUDI VENKATA SUBBARAO; SYED RIYAZ; LIU MIAO
权利人:NAT UNIV SINGAPORE; THE BRIGHAM AND WOMEN’S HOSPITAL INC; INDIAN INSTITUTE OF CHEMICAL TECH
摘要:Provided herein are N-(2-aminophenyl)-prop-2-enamide derivatives, such as those of Formula (I), methods for the synthesis thereof, and uses thereof in the treatment of cancer, such as SALL4-expressing cancer, in a cell or subject in need thereof.

专利号:US-2025178999-A1
优先权日:2022-03-18
标 题:One step synthesis of 1-tetralone compounds and uses thereof in the preparation of (+)-tetralone abscisic acid (aba)
发明人：DIDDI NAVEEN; ABRAMS SUZANNE ROBERTA; LAI LEON
权利人:UNIV SASKATCHEWAN
摘要:The present application is related to a process for preparing 1-tetralone compounds such as compounds of Formula I by reacting a,; 3-unsaturated cyclic ketones that comprise two available hydrogens on the y carbon to the carbonyl with acrolein derivatives with heating in the presence of a suitable organic acid, a suitable organic amine base and suitable inert solvent. For example, the 1-tetralone compound is a tetralone derivative of abscisic acid (ABA).