CAS: 349-43-9; Ethyl 2-Fluoropropionate

相似化合物

72959-95-6 6087-13-4 57965-29-4

上下游产品

ethyl (S)-α-(4-methyl-phenylsulphonyloxy)-propionate ethyl 2-hydroxypropionate ethanol propionyl fluoride1-fluoroethyl phenyl ketone 1,1-diphenyl-2-fluoro-1-propanol 2-fluoro-1-hydroxypropane 2-Fluor-2-methyl-3-phenyl-propionsaeureethylester

L-2-((三氟甲基磺酰基)氧基)丙酸乙酯置于tetrabutylammonium Fluoride Hydrofluoride体系中,用 二氯甲烷 用作溶剂,化学反应生成2-氟丙酸乙酯
参考文献:Nucleophilic Fluorination Of Triflates By Tetrabutylammonium Bifluoride
标题:Nucleophilic Fluorination Of Triflates By Tetrabutylammonium Bifluoride
摘要:Careful Examination Of Nucleophilicity,Basicity,And Leaving Group Ability Led Us To Discover The Nucleophilic Fluorination Of Triflates By Weakly Basic Tetrabutylammonium Bifluoride,Which Provides Excellent Yields With Minimal Formation Of Elimination-Derived Side Products. Primary Hydroxyl Groups As Well As Secondary Hydroxyl Groups In Acyclic Chains Or In Five-Membered Rings Are Excellent Substrates,Whereas Benzylic And Aldol-Type Secondary Hydroxyl Groups Give Poor Yields As A Result Of The Instability Of Their Triflates.
Doi:10.1021/jo8015659

专利信息

专利号:US-9376410-B2
优先权日:2012-10-10
标题 :(2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone and preparation method and use thereof
发明人：WANG GUAN; JIANG XIANGRUI; GONG XUDONG; CHEN WEIMING; ZHU FUQIANG; ZHANG RONGXIA; ZHAO XIANGUO
权利人:TOPHARMAN SHANGHAI CO LTD; SHANGHAI INST MATERIA MEDICA; TOPHARMAN SHANDONG CO LTD; SHANGHAI INST MATERIA MEDICA
摘要:This invention disclose (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone in a single configuration and preparation method and use thereof. The (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone, or a pharmaceutically acceptable salt, an ester, a prodrug or a solvate thereof according to the invention are important intermediates of a variety of anti-viral and anti-tumor active ingredients. A compound obtained from (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone via an acylation reaction can be directly used for preparing various anti-viral and anti-tumor drugs. The Chiral synthesis method and the spontaneous resolution method of the compound of (2R)-2-deoxy-2,2-disubstituted-ribono-1,4-lactone according to the invention have the following advantages: the reaction routes are short and simple with high yield and low cost, which are suitable for industrial application.