CAS: 3518-65-8; Chloromethanesulfonyl Chloride

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CAS号50-00-0 甲醛 | CAS号291-21-4 S-三聚硫代甲 | CAS号4431-79-2 ((((Benzylthio)... | CAS号124-63-0 甲基磺酰氯 | CAS号10352-63-3 Methanesulfonic... | CAS号34557-54-5 methane | CAS号7732-18-5 水 | CAS号7782-50-5 氯气 | CAS号75-73-0 四氟化碳 | CAS号593-70-4 氯氟甲烷 | CAS号75-72-9 氯三氟甲烷 | CAS号335-05-7 三氟甲烷磺酰氟 | CAS号1854-75-7 1,3-dichlorononane | CAS号64544-26-9 chloro(difluoro... | CAS号258516-84-6 二苄基氯甲基磷酸酯 | CAS号35427-68-0 1-chloro-N,N-di... | CAS号229625-50-7 二叔丁基氯甲基磷酸酯 | CAS号107-92-6 正丁酸

1,3,5-三噻烷置于potassium Chlorate体系中,用 盐酸 用作溶剂,化学反应 5.0H,以62%的收率获得氯甲磺酰氯
参考文献:Sulfonamide Analogues Of Creatinine. The Synthesis Of 3-Amino-4,5-Dihydro-1,2,4-Thiadiazole 1,1-Dioxides From Base-Induced Cyclization Reactions
标题:Sulfonamide Analogues Of Creatinine. The Synthesis Of 3-Amino-4,5-Dihydro-1,2,4-Thiadiazole 1,1-Dioxides From Base-Induced Cyclization Reactions
摘要:我们报告了 3-氨基-4,5-二氢-1,2,4-噻二唑 1,1-二氧化物及其 4-甲基衍生物的制备过程. 及其 4-甲基衍生物的制备过程. 肌酐的潜在类似物.噻二唑是从 S-苄基异噻唑的氯甲基磺酰化反应中获得的. S-苄基异硫脲,然后在氯甲基磺酰胺的环化反应中得到噻二唑. 氯甲基磺酰胺在碱性条件下与 2-(叔丁氧基羰酰亚氨基)-2-苯基乙腈或碘甲烷的存在下,在碱性条件下环化得到.
Doi:10.1071/c97159

专利信息

专利号:US-2012053350-A1
优先权日:2009-04-30
标题 :Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
发明人：MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN
权利人:MANGION IAN; HUFFMAN MARK A; RUCK REBECCA T; LYNCH JOSEPH; CHUNG JOHN Y L; MARCUNE BENJAMIN
摘要:A process for the preparation of alkyl esters of N-protected oxo-azacycloalkylcarboxylic acids of Formula III: comprises contacting a ketosulfoxonium ylide of Formula II: with an iridium catalyst to obtain Compound III, wherein P G1 is an amine protective group; k is 0, 1, or 2; and R U , R 1 , R 2 , and R 3 are defined herein. An embodiment of the process further com rises contacting a compound of Formula I: with a sulfoxonium halide of formula (R U ) 3 S(O)Z, wherein Z is halide, in the presence of a strong base to obtain Compound II. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.

专利号:US-9604985-B2
优先权日:2013-06-10
标 题 :Process for the preparation of chiral tert-butyl 4-((1R,2S,5R)-6(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carb derivatives and (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
发明人：MILLER STEVEN P; LIMANTO JOHN; ZHONG YONG-LI; YASUDA NOBUYOSHI; LIU ZHIJIAN
权利人:MERCK SHARP & DOHME
摘要:A process for the preparation of N-protected 6-(piperidin-4-ylcarbamoyl)piperidin-3-yl sulfonates of Formula (III): which comprises contacting a lactone of Formula (II): with an azacycloalkylamine of formula (II-Am): followed by contact with a sulfonyl halide of formula (II-Su): R 4 —SO 2 W (II-Su) in the presence of tertiary amine base, wherein P G1 and P G2 are amine protective groups; k, p and q are 0, 1, or 2, and W, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are defined herein. Additional embodiments add a series of process steps leading to the synthesis of 7-oxo-1,6-diazabicyclo[3.2.1]octanes suitable for use as β-lactamase inhibitors.

专利号:RU-2012557-C1
优先权日:1987-05-29
标 题:Method of synthesis of alkanesulfonanilide derivatives or theirs pharmaceutically acceptable salts

专利号:RU-2098420-C1
优先权日:1993-09-11
标 题:Cephalosporin compounds, their pharmaceutically acceptable nontoxic salts, physiologically hydrolyzable esters, isomers having e-configuration of double bond in propenyl group, syn-isomers and optical isomers and a method of their synthesis

专利号:CN-116874440-A
优先权日:2023-06-21
标题:Synthesis and application of isoxazoline-containing derivative