CAS: 372118-01-9; Methyl 4,6-Dichloropyridazine-3-Carboxylate

相似化合物

679406-03-2 2245111-15-1 65202-50-8

1,3-丙酮二羧酸二甲酯置于三乙胺,三苯基膦,三氯氧磷体系中,用 乙醚,乙腈 作为反应溶剂,化学反应 31.0H,反应生成 4,6-二氯哒嗪-3-羧酸甲酯
参考文献:Sulfone Pyridine Alkyl Amide-Substituted Heteroaryl Compounds
标题:Sulfone Pyridine Alkyl Amide-Substituted Heteroaryl Compounds
摘要:具有以下化学式i的化合物,或其立体异构体或药用可接受的盐,其中r1,R2,R3,R4和r5如本文所定义,在通过作用于tyk-2引起信号转导抑制的过程中,对il-12,Il-23和/或ifnα的调节是有用的.

专利信息

专利号:WO-2025078335-A1
优先权日:2023-10-09
标 题 :Processes for the preparation of deucravacitinib
发明人：ETAYO PÉREZ PABLO; PUJOL OLLÉ XAVIER; MOLINA NIETO JUAN
权利人:FARMHISPANIA GROUP S L
摘要:The invention relates to processes for the preparation of deucravacitinib of formula (XI), or a pharmaceutically acceptable salt thereof. It also relates to intermediates of formula (V') and (V'') as defined herein useful in the synthesis of this molecule.

专利号:US-11731956-B2
优先权日:2018-10-22
标 题:Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.

专利号:WO-2022162606-A1
优先权日:2021-01-30
标 题:Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：YAN ZHIYU; WANG XIAOHUI; LIU HANLAN; KHAN PASHA M; PANPATIL DAYANAND; PUJALA BRAHMAM; PENDHARKAR DHANANJAY; JADHAVAR PRADEEP S; SAEED UZMA; KUMAR VIVEK
权利人:SPEROGENIX THERAPEUTICS LTD; INTEGRAL BIOSCIENCES PRIVATE LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (J), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes such as cancer, idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed. Formula (J)

专利号:CN-118561839-A
优先权日:2024-05-13
标 题:Synthesis method of N-(8-oxo-7,8-dihydropyrido[3,4-c]pyridazine-3-yl)cyclopropanecarboxamide