CAS: 4373-41-5; (4As,6As,6Br,8Ar,10R,11R,12Ar,12Br,14Bs)-10,11-Dihydroxy-2,2,6A,6B,9,9,12A-Heptamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene-4A-Carboxylic Acid

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CAS号464876-77-5 Benzyl (2α,3β)-... | CAS号22425-82-7 马斯里酸甲酯 | CAS号508-02-1 齐墩果酸 | CAS号303114-51-4 齐墩果酸苄酯 | CAS号869788-75-0 benzyl (4aS,6aS... | CAS号6089-92-5 (2α,3β)- 2,3-Bi... | CAS号14464-51-8 Olean-12-ene-2a...

2-硒吩亚磺酸,5-甲基-置于palladium On Activated Charcoal Sodium Tetrahydroborate,氢气体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 山楂酸
参考文献:五环三萜.第2部分:作为糖原磷酸化酶抑制剂的山楂酸衍生物的合成和生物学评估.
标题:五环三萜.第2部分:作为糖原磷酸化酶抑制剂的山楂酸衍生物的合成和生物学评估.
摘要:描述了一系列山楂酸衍生物的合成,并评估了它们对兔肌肉糖原磷酸化酶的作用.在这一系列化合物中,15(ic(50)= 7 Microm)是最有效的gpa抑制剂.讨论了山梨酸衍生物的sar.
DOI:10.1016/j.Bmcl.2005.10.014

专利信息

专利号:WO-2007002173-A1
优先权日:2005-06-22
标 题:Hiv-1 protease inhibitors, and methods of making and using them
发明人：RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
权利人:UNIV MASSACHUSETTS; RANA TARIQ M; ALI AKBAR; CAO HONG; SAI KIRAN KUMAR REDDY GA; ANJUM SAIMA GHAFOOR
摘要:One aspect of the invention relates to the design, synthesis and biological activity of novel HIV-1 protease inhibitors incorporating N-phenyloxazolidine-5-carboxamides into the (hydroxyethylamino)sulfonamide scaffold as P2 ligands. For example, the present invention relates to inhibitors with variations at the P2 phenyloxazolidine and the P2' phenylsulfonamide moieties. Remarkably, compounds with an (S)-enantiomer of substituted phenyloxazolidines at P2 show highly potent inhibitory activities against wild-type HIV-1 protease. In certain embodiments, the inhibitors of the invention have Ki values in low picomolar (pM) range. In certain embodiments, the inhibitors of the invention were shown to be active against a variety of multi-drug resistant (MDR) HIV-1 proteases, each representing different paradigm of drug resistance.

专利号:BR-102013002260-B1
优先权日:2013-01-30
标题:Synthesis of new 1,2,3-triazoles, composition, uses and method

专利号:CN-115074399-A
优先权日:2021-03-12
标题 :The key enzyme genes EjCYP716A1/2 and EjCYP716C1/2 of loquat triterpene acid synthesis and their applications

专利号:US-2010093823-A1
优先权日:2008-04-30
标 题 :Steroidal compounds as melanogenesis modifiers and uses thereof
发明人：ORLOW SETH J; KOMATSU LI NI
权利人:ORLOW SETH J; KOMATSU LI NI
摘要:A method for the identification of compounds) that control melanin synthesis (melanogenesis), and the preparation and use of such compounds, and compositions and formulations thereof to modify (e.g., inhibit) melanin production are disclosed. A representative compound of the invention is defined by formula I: n n n n n n n n n n The compounds may be prepared as pharmaceutical and cosmetic compositions, and in one embodiment, may be prepared in combination with each other, and with other melanogenesis inhibiting formulations. The compounds, compositions and formulations of the invention may be used for the prevention and treatment of conditions that are causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.

专利号:CN-115074374-B
优先权日:2021-03-12
标题 :The key enzyme genes MdCYP716A2 and MdCYP716C1 of apple triterpene acid synthesis and their application

专利号:CN-103725743-A
优先权日:2014-01-06
标 题:Biocatalytic synthesis method of corosolic acid