专利号:US-12201669-B2 优先权日:2021-03-11 标 题:Small molecule suppressors of APOE gene expression and cerebral vascular amyloid pathology 发明人:TSAI LI-HUEI; BLANCHARD JOEL 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:The present disclosure provides methods of inhibiting amyloid synthesis in a subject using small molecule inhibitors. The invention also includes methods of treating disease associated with amyloid synthesis, such as Alzheimer's disease. The small molecule inhibitors disclosed herein are compounds which are non-immunosuppressant cyclosporin including the pharmaceutically acceptable salts thereof.
专利号:US-2007065377-A1 优先权日:2003-10-17 标题 :Composition for promoting synthesis of collagen, and composition for external preparation for skin comprising the same
专利号:WO-2021038306-A1 优先权日:2019-08-28 标 题 :Selenophenochromene phosphonic acids, preparation and use as antiproliferative agents 发明人:ARSENJANS PAVELS; DOMRACEVA ILONA; PAEGLE EDGARS 权利人:LATVIAN INST ORGANIC SYNTHESIS 摘要:The present invention relates to a novel selenophenochromene phosphonic acids as antiproliferative agents, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment or prevention of various diseases and disorders by administration of such substances.
专利号:WO-2005037270-A1 优先权日:2003-10-17 标题:Composition for promoting synthesis of collagen, and composition for external preparation for skin comprising the same
专利号:US-2009233997-A1 优先权日:2003-10-17 标题 :Composition for promoting synthesis of collagen, and composition for external preparation for skin comprising the same
专利号:US-10112881-B2 优先权日:2014-07-21 标题:Skin lightening compounds 发明人:Huang cheng-chen; MONTE AARON P 权利人:WISYS TECH FOUNDATION INC 摘要:The present invention provides a compound of Formula I, n n n n n n n n n n n n wherein R 1 is not H when R 2 is H and R 2 is not H when R 1 is H, further wherein R 1 is C n H (2n+1) O, wherein n is 1-10, R 2 is OH or C n H (2n+1) O, wherein n is 1-10, A, B and R 1 , R 2 , R 5 , R 6 , and R 7 are separately and independently selected from a group consisting of H, alkyl, hydroxyl, halo, nitro and aryl groups, R 11 is an alkyl or an aryl group and L is an optional linker or linking group, with x=0 or 1, i.e., if x=0, no linking group is present, or a salt or prodrug or derivative thereof that is a skin-lightening agent useful for the inhibition of melanin synthesis and/or the removal of existing melanin to function as a skin-lightening agent.
1: Nickel JC, Herschorn S, Whitmore KE, Forrest JB, Hu P, Friedman AJ, Baseman AS. Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: insights from a randomized, double-blind, placebo controlled study. J Urol. 2015 Mar;193(3):857-62. doi: 10.1016/j.juro.2014.09.036. Epub 2014 Sep 20. doi: 10.1371/journal.pone.0100882. eCollection 2014. 3: Pirgozliev V, Rose SP, Pellny T, Amerah AM, Wickramasinghe M, Ulker M, Rakszegi M, Bedo Z, Shewry PR, Lovegrove A. Energy utilization and growth performance of chickens fed novel wheat inbred lines selected for different pentosan levels with and without xylanase supplementation. Poult Sci. 2015 Feb;94(2):232-9. doi: 10.3382/ps/peu059. Epub 2015 Jan 16. 4: Kramer CM, Tsang AS, Koenig T, Jeffcott LB, Dart CM, Dart AJ. Survey of the therapeutic approach and efficacy of pentosan polysulfate for the prevention and treatment of equine osteoarthritis in veterinary practice in Australia. Aust Vet J. 2014 Dec;92(12):482-7. doi: 10.1111/avj.12266. doi: 10.1016/j.biomaterials.2013.10.056. Epub 2013 Nov 8. doi: 10.1007/s13365-014-0244-8. Epub 2014 Mar 27. doi: 10.1016/j.biortech.2012.12.088. Epub 2012 Dec 20. doi: 10.1136/jnnp-2013-305590. Epub 2014 Feb 19.
合成参考文献
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