CAS: 7069-42-3; (2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-Trimethylcyclohex-1-En-1-yl)Nona-2,4,6,8-Tetraen-1-Yl Propionate

该化合物是维生素A的一种稳定酯衍生物,在化妆品和药剂配方中提高了稳定性和功效; 将丁基羟丁酸(丁基羟丁基羟丁基甲酸)作为抗氧化剂,可以最大限度地减少氧化降解,确保长期储存寿命和连续性能; 纯度为90%,该化合物为最佳皮肤效益提供了平衡的浓度,包括改善细胞循环和凝聚; 其经强化的形态可以提高皮肤渗透,同时减少对视他醇的刺激,使之适合敏感的皮肤应用; 产品对于抗养殖,丙烯治疗和皮肤更新配方十分理想,在最低的不稳定性情况下产生可靠的效果.

结构式图片

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号302-79-4 维生素A酸; 视黄酸 | CAS号81121-20-2 4-甲氧基视黄酸

合成工艺路线路线简述

  • 合成目标产物 Retinyl Propionate 主要起始原料 Vitamin A And Propionic-2,3-14C1 Acid (8Ci)
  • (文献来源)合成步骤主要原料 Vitamin A 和 Propionic-2,3-14C1 Acid (8Ci)
(2E)-Farnesal置于硫酸,对甲苯磺酸,三苯基膦,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 甲醇,环己烷,1,2-二氯乙烷,甲苯 作为反应溶剂,化学反应 4.5H,反应生成 维生素a丙酸酯
参考文献:一种维生素a及维生素a酯制备方法
标题:一种维生素a及维生素a酯制备方法
摘要:本发明提供了一种以法尼醇为原料制备维生素a及维生素a酯的新方法.包含如下步骤:法尼醇在催化剂和助催化剂作用下与氧气发生氧化反应反应生成法尼醛;法尼醛发生脱氢反应反应生成去氢法尼醛;去氢法尼醛在酸催化下发生环化反应,反应生成环化中间体;环化中间体与氯代异戊烯醇发生反应,反应生成维生素a;维生素a发生酯化反应反应生成维生素a酯.所述方法避免了现有工艺的缺点,工艺线经济有效.

海关参考信息

专利信息


专利号:US-7618662-B2
优先权日:2004-12-22
标题:Use of natural plant extracts in cosmetic compositions
发明人:HINES MICHELLE D; DUGGAN MICHELE C; BINETTI RALPH R
权利人:AVON PROD INC
摘要:The present invention describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis. The plant extracts are preferably derived from Rhinacanthus nasutus, Humulus scandens, Sesbania grandiflora, Amorphophallus campanulatu, Pouzolzia pentandra , and Piper betel , and any combinations thereof. The compositions are preferably applied to the skin, or are delivered by directed means, to a site in need thereof.

专利号:US-2012237623-A1
优先权日:2009-12-04
标题 :Topical Compositions Containing Derris Scandens Benth and a Method of Treating Skin
发明人:PTCHELINTSEV DMITRI S; LUO XIAOCHUN
权利人:PTCHELINTSEV DMITRI S; LUO XIAOCHUN; AVON PROD INC
摘要:Topical compositions and methods of use to treat symptoms of reduced skin elasticity are provided comprising extracts of a. Derris scandens Benth. plant. These compositions are effective in stimulating LOXL-1, activity, inhibiting calcineurin activity, and stimulating glycosaminoglycan synthesis in skin cells and can thus reduce age-related skin damage and improve appearance of fine lines, wrinkles, skin sagging and other symptoms of skin aging and/or skin damage.

专利号:US-8575106-B2
优先权日:2009-08-31
标题:Cosmetic uses of modified stressed yeast extracts and related compositions
发明人:SANTHANAM UMA; KYROU CHRISTOS D; MAZICH DESIREE; HONG QI; SHAHEEN HUSSAM H
权利人:SANTHANAM UMA; KYROU CHRISTOS D; MAZICH DESIREE; HONG QI; SHAHEEN HUSSAM H; AVON PROD INC
摘要:Cosmetic compositions comprising a metal-complexed peptide fraction of stressed yeast extracts and/or a calcium influx inhibitor are disclosed, as well as methods of using such compositions to impart exfoliating, anti-aging, anti-lipid, anti-inflammatory, and/or lightening benefits to the skin; and/or lightening benefits to the hair. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging, inflammation, lipid synthesis, and melanin production.

专利号:EP-2153815-A1
优先权日:2008-08-05
标题 :Use of urea containing compositions
发明人:TRULLAS CABANAS CARLOS RAMON; KRUTMANN JEAN PROF DR
权利人:ISDIN SA
摘要:The present invention relates to the use of a composition comprising urea for increasing the expression of at least one gene associated with the collagen synthesis within the dermis of the skin. nThe urea composition has been used for preventing/treating damages of the skin such as signs of aging, wrinkles, damages associated with UV-radiation, wounds, skin diseases.

专利号:US-2015366923-A1
优先权日:2013-03-14
标题 :Allamanda cathartica extracts and methods of use
发明人:MEI BING C; LYGA JOHN W
权利人:AVON PROD INC
摘要:Methods of using extracts of Allamanda cathartica to impart benefits to skin and/or improve skin conditions resulting from aging or damaged skin are provided, said methods comprising applying the extacts of Allamanda cathartica in pharmaceutically and cosmetically acceptable formulations to the skin surface, which results in activation of collagen synthesis and leads to skin lightening and anti-wrinkle effects.

专利号:US-2013224318-A1
优先权日:2012-02-29
标 题 :Use of CPT-1 Modulators and Compositions Thereof
发明人:HWANG CHENG S; YIM SUNGHAN; SANTHANAM UMA; LYGA JOHN W
权利人:AVON PROD INC; AVON PROD INC
摘要:The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.
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主要参考文献

Donoghue S, Kronfeld DS, Berkowitz SJ, Copp RL. Vitamin A nutrition of the equine: growth, serum biochemistry and hematology. J Nutr. 1981 Feb;111(2):365-74. doi: 10.1093/jn/111.2.365.

合成参考文献


参考文献:10.1007/s00105-011-2137-6
摘要:Kerscher M, Buntrock H. [Anti-aging creams. What really helps ]. Hautarzt. 2011 Aug;62(8):607–13. doi: 10.1007/s00105-011-2137-6.
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