CAS: 86393-34-2; 2,4-Dichloro-5-Fluorobenzoyl Chloride

该化合物是一种有机化合物,其特点是其芳香结构,其特点是一种含有两个氯原子的苯化物和苯环上一个氟原子替代物的苯化物;该化合物的形态和纯度一般是淡黄色液体或固态的无色物质,因其具有反应性而闻名,特别是由于乙基氯的功能组的存在,使其在各种化学反应中,包括在相互交织和组合反应中,成为强大的电极;氯和氟原子的存在,增强了其生物活动,并能够影响其溶解性和稳定性. 2,4-二氯-5-氟苯基氯经常用于合成药品,农用化学品和其他精密化学品.与许多乙烷一样,它对水十分敏感,能够与水产生强烈反应,释放盐酸.在惰性大气中进行适当处理和储存对于保持其稳定性和防止水解至关重要.

英文名称2,4-Dichloro-5-Fluorobenzoyl Chloride
中文名称2,4-二氯-5-氟苯甲酰氯
IUPAC名称2,4-dichloro-5-fluorobenzoyl chloride
其它别名2,4-Dichloro-5-Fluorobenzoyl Chloride, ; C7H2Cl3Fo; 24-Dichloro-5-Fluorobenzoyl Chloride; 2,4-Dichloro-5-Fluorobenzoyl Chloride; 2,4-Dichloro-5-Fluoro-Benzoyl Chloride; Ft
CAS编号86393-34-2
MFCD编号:MFCD00075341
EINECS号:622-285-6
分子式:C7H2Cl3FO
分子量:227.45
产品CID: 1865372
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: RPZXUSJCSDQNTE-UHFFFAOYSA-N
InChI=1S/C7H2Cl3FO/c8-4-2-5(9)6(11)1-3(4)7(10)12/h1-2H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼损伤类别1
皮肤致敏类别1
水生慢性毒性类别3
警示词Danger(危险)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H318 |造成严重眼损伤.
H317 |可能引起皮肤过敏反应.
H412 |对水生生物有害并具有长期持续影响.
防范说明P234-P260-P261-P264-P272-P273-P280-P301+P330+P331-P302+P352-P304+P340-P362+P364-P363-P390-P405-P406-P501
危险等级8
UN编号3265.0
危险品标志C
风险等级Corrosive
包装等级Ⅱ
安全声明26-27-28-36/37/39-45
危险类别码34-36/37
WGK Germany1

欧盟法规

C&L通报

上下游产品

2,4-Dichloro-5-Fluoro-(Trichloromethyl)Benzene
2,4-二氯-5-氟苯甲酸 2,4-Dichloro-5-Fluoro-Benzoic Acid 86522-89-6
2,4-二氯-5-氟苯乙酮 2,4-Dichloro-5-Fluoroacetophenone 704-10-9
Dichloro-Bis(2,4-Dichloro-5-Fluorophenyl)Methane

合成工艺路线路线简述

合成目标产物 2,4-Dichloro-5-Fluorobenzoyl Chloride 主要起始原料 2,4-Dichloro-5-Fluorobenzoic Acid
103318-75-8 = 86393-34-2
反应条件:1.1 Reagents: Sodium Hydroxide,Water Solvents: Ethanol2.1 Reagents: Thionyl Chloride
标题:Synthesis Of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives As Potential Chemotherapeutic Agents
作者:Rudolf,Manfred
参考文献:1985]

153500-77-7 = 86393-34-2
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Cuprous Chloride Solvents: Water2.1 Reagents: Sodium Hydroxide,Water Solvents: Ethanol3.1 Reagents: Thionyl Chloride
标题:Synthesis Of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives As Potential Chemotherapeutic Agents
作者:Rudolf,Manfred
参考文献:1985]

86522-86-3 = 86393-34-2 [标题:Reaction Conditions
标题:2,4-Dichloro-5-Fluorobenzoyl Chloride
参考文献:Federal Republic Of Germany]

17601-75-1 = 86393-34-2 [标题:Reaction Conditions
标题:2,4-Dichloro-5-Fluorobenzoyl Chloride
参考文献:Federal Republic Of Germany]

367-21-5 = 86393-34-2
反应条件:1.1 -2.1 -2.2 -3.1 -4.1 Reagents: Thionyl Chloride Catalysts: Dimethylacetamide Solvents: Toluene4.2 90 Min,Reflux
标题:In Situ Process For The Synthesis Of Ciprofloxacin
作者:Coll,Alberto Palomo; Et Al
参考文献:Afinidad 日期:2001 卷标:58(494) 页码:276-280]

86522-89-6 = 86393-34-2
反应条件:1.1 Reagents: Thionyl Chloride
标题:Synthesis Of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives As Potential Chemotherapeutic Agents
作者:Rudolf,Manfred
参考文献:1985]

86522-89-6 = 86393-34-2
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Sulfuric Acid; 48 Min,Reflux
标题:Bronsted Acid-Catalyzed Chlorination Of Aromatic Carboxylic Acids
作者:Yu,Zhiqun; Et Al
参考文献:Phosphorus 日期:2021 卷标:196(8) 页码:685-689]

1435-48-9 = 86393-34-2
反应条件:1.1 Reagents: Aluminum Chloride Solvents: Chloroform; 2 H,Rt; Rt -> 65 °C; 3 - 5 H,65 °C
标题:New Synthetic Process Of Cycloprophyl Carboxylic Acid
作者:Lu,Wei; Et Al
参考文献:Guangzhou Huagong 日期:2013 卷标:41(15) 页码:101-102]

1435-48-9 = 86393-34-2
反应条件:1.1 Reagents: Aluminum Chloride
标题:A Novel Approach To Finafloxacin Hydrochloride (Bay35-3377)
作者:Hong,Jian; Et Al
参考文献:Tetrahedron Letters 日期:2009 卷标:50(21) 页码:2525-2528]

1435-48-9 = 86393-34-2
反应条件:1.1 -1.2 -2.1 -3.1 Reagents: Thionyl Chloride Catalysts: Dimethylacetamide Solvents: Toluene3.2 90 Min,Reflux
标题:In Situ Process For The Synthesis Of Ciprofloxacin
作者:Coll,Alberto Palomo; Et Al
参考文献:Afinidad 日期:2001 卷标:58(494) 页码:276-280]

108288-16-0 = 86393-34-2
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Cuprous Chloride Solvents: Water2.1 Reagents: Thionyl Chloride
标题:Synthesis Of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives As Potential Chemotherapeutic Agents
作者:Rudolf,Manfred
参考文献:1985]

704-10-9 = 86393-34-2
反应条件:1.1 Reagents: Sodium Hypochlorite Solvents: Water; 3 H,80 °C; 80 °C -> 50 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 22.1 Reagents: Thionyl Chloride; Rt -> 68 °C; 4 H,Reflux; Reflux -> 84 °C; 1 H,84 °C
标题:Novel Method For The Preparation Of Grignard'S Reagent And It'S Application In The Synthesis Of Ciprofloxacin
作者:An,Yongbin; Et Al
参考文献:Zhongguo Kangshengsu Zazhi 日期:2004 卷标:29(9)]

104901-79-3 = 86393-34-2
反应条件:1.1 Reagents: Sodium Hydroxide,Water Solvents: Ethanol2.1 Reagents: Sodium Nitrite,Hydrochloric Acid,Cuprous Chloride Solvents: Water3.1 Reagents: Thionyl Chloride
标题:Synthesis Of Heterocyclic Annellated Pyridone Carboxylic Acid Derivatives As Potential Chemotherapeutic Agents
作者:Rudolf,Manfred
参考文献:1985

2,4-二氯氟苯置于aluminum (Iii) Chloride,Iron(Iii) Chloride体系中,化学反应 8.0H,反应生成 2,4-二氯-5-氟苯酰氯
参考文献:一种2,4-二氯-5-氟苯甲酰氯绿色生产工艺
标题:一种2,4-二氯-5-氟苯甲酰氯绿色生产工艺
摘要:本发明涉及化学领域,具体提供了一种2,4‑二氯‑5‑氟苯甲酰氯的绿色生产工艺,本发明将四氯化碳法生产2,4‑二氯‑5‑氟苯甲酰氯的二聚副产物在催化剂作用下碱解,再经酸化后和主反应缩合反应生成的三氯化物反应转化为2,4‑二氯‑5‑氟苯甲酰氯,收率达到99.8%以上.

海关参考信息

2903919090-氯苯
2912110000-甲醛
2912210000-苯甲醛
2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-5792892-A
优先权日:1994-04-28
标题:Processes for preparing aromatic, bromine-containing compounds, novel bromine-containing compounds, and their use as intermediate products in the synthesis of active agents
发明人：HAGEMANN HERMANN
权利人:BAYER AG
摘要:The present invention relates to processes for the preparation of bromine-containing aromatic compounds, to novel bromine-containing compounds and to their use as intermediates in the synthesis of active substances. Processes according to the invention for the preparation of known and novel bromine-containing compounds are characterized by specific conditions.

专利号:US-11174266-B2
优先权日:2018-02-13
标题 :Efficient process for the preparation of sitagliptin
发明人：SHI TERRY; LOU SAM; DE LUCCHI OTTORINO; PADOVAN PIERLUIGI
权利人:F I S â€”FABBRICA ITALIANA SINTETICI S P A
摘要:Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.

专利号:US-11059788-B2
优先权日:2017-06-12
标题:Streamlined syntheses of fluoroquinolones
发明人：GUPTON FRANK B; TOSSO PERRER N
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods of synthesizing fluoroquinolones such as ciprofloxacin are provided. The methods utilize affordable materials, reduce the number of synthesis steps and provide high yields.

专利号:EP-0757667-A1
优先权日:1994-04-28
标题 :Processes for preparing aromatic, bromine-containing compounds, novel bromine-containing compounds, and their use as intermediate products in the synthesis of active agents

专利号:CN-111032622-A
优先权日:2017-06-12
标题 :Streamlined Synthesis of Fluoroquinolones

专利号:WO-9529886-A1
优先权日:1994-04-28
标题:Processes for preparing aromatic, bromine-containing compounds, novel bromine-containing compounds, and their use as intermediate products in the synthesis of active agents