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2,6-dichloro-4-(trifluoromethyl)aniline 1-trifluoromethyl-3,4,5-trichlorobenzene ammonium hydroxide 1,2-dichloro-3-fluoro-5-trifluoromethylbenzene 合成工艺路线路线简述
- 50594-82-6 = 86398-94-9
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Pyridine,Water; Rt -> 150 °C; 15 H,150 °C
标题:Research On The Synthesis Crafts Of 5-Amino-1-[2,6-Dichloro-4-(Trifluoromethyl)Phenyl]-4-[(Trifluoromethyl)Sulfinyl]-1H-Pyrazole-3-Carbonitrile (Fipronil)
作者:Zhao,Hai-Yun; Et Al
参考文献:Xiandai Nongyao 日期:2008 卷标:7(4) 页码:17-21]
24279-39-8 = 86398-94-9
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; Rt; 3 °C; 3 °C; 5 °C; 30 Min,5 °C1.2 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Ethanol,Water; 0 °C; 1 H,0 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 7,0 °C
标题:Synthesis Of Trifluoromethyl Containing 5-Pyrazolone Derivatives
作者:Li,Shuyan; Et Al
参考文献:Jingxi Shiyou Huagong Jinzhan 日期:2017 卷标:18(1) 页码:55-57]
= 86398-94-9
反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; 40 Min,50 - 60 °C; 60 °C -> 80 °C; 1 H,80 °C; 80 °C -> 100 °C; 4 H,100 °C; 100 °C -> 115 °C; 2 H,115 °C; 3 - 4 H,115 °C -> 70 °C1.2 Reagents: Water; Cooled2.1 Reagents: Chlorine Catalysts: Azobisisobutyronitrile; Rt -> 230 °C; 16 H,230 °C3.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Pyridine,Water; Rt -> 150 °C; 15 H,150 °C
标题:Research On The Synthesis Crafts Of 5-Amino-1-[2,6-Dichloro-4-(Trifluoromethyl)Phenyl]-4-[(Trifluoromethyl)Sulfinyl]-1H-Pyrazole-3-Carbonitrile (Fipronil)
作者:Zhao,Hai-Yun; Et Al
参考文献:Xiandai Nongyao 日期:2008 卷标:7(4) 页码:17-21]
50594-82-6 = 86398-94-9
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Pyridine,Water; Rt -> 150 °C; 15 H,150 °C; Cooled
标题:Synthesis Of 2,6-Dichloro-4-Trifluoromethylaniline Via Hydrazinolysis And Hydrogenolysis And Reduction
作者:Lan,Yanna; Et Al
参考文献:Jingxi Huagong Zhongjianti 日期:2005 卷标:35(4) 页码:30-32]
24279-39-8 = 86398-94-9
反应条件:1.1 Reagents: Sodium Nitrite,Hydrochloric Acid Solvents: Water; 2 H,0 °C1.2 Reagents: Hydrochloric Acid,Stannous Chloride Solvents: Water; 7 °C; 1 H,7 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 8
标题:Synthesis Of Novel 1-[(2,6-Dichloro-4-Trifluoromethyl)Phenyl]-3-Aryl-1H-Pyrazole-4-Carbaldehydes
作者:Hu,Huanan; Et Al
参考文献:Molecules 日期:2010 卷标:15 页码:7472-7481]
393-75-9 = 86398-94-9
反应条件:1.1 Reagents: Chlorine Catalysts: Azobisisobutyronitrile; Rt -> 230 °C; 16 H,230 °C2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Pyridine,Water; Rt -> 150 °C; 15 H,150 °C
标题:Research On The Synthesis Crafts Of 5-Amino-1-[2,6-Dichloro-4-(Trifluoromethyl)Phenyl]-4-[(Trifluoromethyl)Sulfinyl]-1H-Pyrazole-3-Carbonitrile (Fipronil)
作者:Zhao,Hai-Yun; Et Al
参考文献:Xiandai Nongyao 日期:2008 卷标:7(4) 页码:17-21
3,4,5-三氯三氟甲苯置于一水合肼体系中,用 吡啶,水 作为反应溶剂,化学反应生成 2,6-二氯-4-三氟甲基苯肼
参考文献:4-Cyano(Nitro)-5-Oxy(Thio)-Pyrazole Derivatives,Composition Containing
标题:4-Cyano(Nitro)-5-Oxy(Thio)-Pyrazole Derivatives,Composition Containing
摘要:化学式为##str1##的新型除草剂和植物生长调节剂吡唑酮,其中r.Sup.1代表氢,烷基或卤代烷基,R.Sup.2代表硝基或氰基,R.Sup.3代表可选取代的烷基,可选取代的烯基,可选取代的炔基,可选取代的环烷基,可选取代的环烷基烷基,可选取代的芳基烷基或可选取代的芳基,Ar代表取代两次或更多的苯基或可选取代的吡啶基,Y代表o,S,So或so.Sub.2.其中还有几个中间体是新的.
专利信息
专利号:US-7094906-B2
优先权日:1998-04-20
标 题:Processes for preparing pesticidal intermediates
发明人:ANCEL JEAN-ERICK
权利人:BASF AGRO BV
摘要:The present invention relates to processes for the preparation of a compound of the formula n nwherein W is nitrogen or —CR 3 ; R 1 is halogen, haloalkyl, haloalkoxy, R 4 S(O) n — or —SF 5 ; R 2 is hydrogen or halogen; R 3 is halogen; R 4 is alkyl or haloalkyl; and n is 0, 1 or 2; and processes for using a compound of the formula (I) in the synthesis of compounds of the formula
专利号:US-6409988-B1
优先权日:1999-07-01
标 题:Radiolabeled 1-aryl pyrazoles, the synthesis thereof and the use thereof as pest GABA receptor ligands
发明人:DHANOA DALJIT S; MEEGALLA SANATH; DOLLER DARIO; SOLL RICHARD M
权利人:DIMENSIONAL PHARM INC
摘要:The present invention is directed to radiolabeled compounds of Formula I:or salts thereof, whereR1 represents R8, R8O, R8SO2, R8SO or R8S in which R8 is tritiated or deuterated methyl;X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substitutedC6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond;R2 is hydrogen or amino; andR3-R7 are defined in the specification.The invention is also directed to methods of using such compounds for demonstrating specific insect GABA receptors, qualitatively screening for compounds acting on an insect GABA receptor or quantitatively assaying concentrations of a compound acting on an insect GABA receptor.
专利号:US-6518266-B1
优先权日:1999-07-22
标题:1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides
发明人:DHANOA DALJIT S; DOLLER DARIO; MEEGALLA SANATH; SOLL RICHARD M; WISNEWSKI NANCY; SILVER GARY; STINCHCOMB DAN T; SEWARD R LEE; AGRAFIOTIS DIMITRIS; SHA DEYOU
权利人:DIMENSIONAL PHARMACEUTICALS 3; HESKA CORP
摘要:The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I:or a salt thereof, whereR1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein;X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond;R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; andR3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.
专利号:JP-2006523677-A
优先权日:2003-04-17
标题:Method for the synthesis of 5-chloro-1-aryl-4- (4,5-dicyano-1H-imidazol-2-yl) -3-alkyl-1H-pyrazole derivatives
专利号:US-6258973-B1
优先权日:1997-03-03
标 题 :Processes for preparing pesticidal intermediates
发明人:D SILVA THEMISTOCLES D J; ANCEL JEAN-ERICK
权利人:RHONE POULENC AGROCHIMIE
摘要:The invention relates to a process for the preparation of compounds having the formula (I) n wherein W, R 2 , R 3 , R 5 and R 6 are as defined in the description, which are useful as intermediates in the synthesis of pesticidally active compounds.
专利号:US-6545033-B1
优先权日:1999-10-06
标 题:Fused 1-(2,6-dichloro-4-trifluoromethylphenyl)-pyrazoles, the synthesis thereof and the use thereof as pesticides
发明人:DHANOA DALJIT S; MEEGALLA SANATH; SOLL RICHARD M; DOLLER DARIO; SHA DEYOU; LIU RUIPING; SILVER GARY; LEE YU-KAI
权利人:DIMENSIONAL PHARM INC
摘要:The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I:or a salt thereof, whereR1 is amino, hydrogen, alkyl, hydroxy, halo, alkoxy, alkylamino, dialkylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, trifluoroalkylsulfinyl, trifluoroalkylsulfonyl, hydroxy, amino, trifluoromethyl, acetylamino, -OSO2R2, -OS(O)R2, -OC(O)R2, -OC(O)NHR2, or -NHC(O)NHR2 where R2 is C1-4 alkyl or optionally substituted aryl;X, Y and Z are each independently (CH)n, (CR3R4)n, S, S(O), or SO2, wherein n is 1-2, R3 and R4 are defined herein;Q is N or C-R6, wherein R6 is fluoro, chloro, bromo, or iodo;R5 is halo, C1-C6 alkyl, C1-C4 alkenyl, C1-C4 alkoxy, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, C1-C4 alkylsulfonyl, C1-C4 trifluoroalkylsulfinyl, C1-C4 trifluoroalkylsulfonyl, hydroxy, amino, or trifluoromethyl; andwith the proviso that only one of X, Y and Z can be S, S(O) or SO2.