CAS: 13756-42-8; Tert-Butyl 4-Methylbenzoate

相似化合物

99-94-5 774-65-2 65874-27-3

上下游产品

4-methyl-benzoyl chloride tert-butyl alcoholtert-butyl alcohol p-Toluic acid tert-butylatepotassium tert-butylate 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester tert-butyl 1,4-dihydro-p-toluate 4-[2-Carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzoic acid tert-butyl ester

对甲基苯甲酰氯置于吡啶体系中,用 叔丁醇 用作溶剂,以96%的收率获得4-甲基苯甲酸叔丁酯
参考文献:Matrix Metalloproteinase Inhibitors
标题:Matrix Metalloproteinase Inhibitors
摘要:提供了一些与mmp-13的催化结构域发生变构结合的化合物,包括一个疏水基团,第一和第二氢键受体,以及至少一个,最好是两个,第三氢键受体和第二疏水基团.上述特征的质心的笛卡尔坐标在说明书中定义.当配体与mmp-13结合时,第一,第二和第三(存在时)氢键受体分别与thr245,Thr247和met253结合,第一个疏水基团位于mmp-13的s1'通道内,第二疏水基团(存在时)相对于溶剂是开放的.这些化合物特异性地抑制基质金属蛋白酶-13酶,因此可用于治疗由组织分解引起的疾病,如心脏病,多发性硬化症,关节炎,动脉粥样硬化和骨质疏松症.

专利信息

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:US-4219489-A
优先权日:1978-09-05
标题:Synthesis of steroids
发明人：BUNES LEONARD A; JOHNSON WILLIAM S
权利人:STANFORD LELAND JUNIOR UNIV TR
摘要:Method and compounds are provided for use in the synthesis of steroids wherein a polyolefin is provided having an initiating group having a chalcogen atom in juxtaposition to a double bond, so as to be capable of bond formation to close to form a ring and having a terminating group involving pi unsaturation (a double or triple bond) conjugated to an aromatic ring. Upon acid catalysis, sigma bonds are formed through the interaction of a carbocation formed at the carbon atom bonded to the chalcogen atom and the double bond intermediate the initiating group and the terminating group, which close to form rings of a steroid nucleus, the carbocation interacting with the pi unsaturation conjugated with the aromatic group and being captured by a nucleophile present in the acidic reaction medium. The resulting steroid product may then be modified in known ways to produce known steroids.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:US-2016311847-A1
优先权日:2015-04-24
标题:Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support

专利号:WO-2012011939-A2
优先权日:2010-07-19
标 题 :Synthesis of cyclopentaquinazolines

专利号:US-8691836-B2
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use