正癸酸,二甲胺 以 水 用作溶剂,240.0 °C,2.0 Mpa 条件下,反应 0.17H,反应生成N,N-二甲基癸酰胺 参考文献:Method For Producing Amides In The Presence Of Superheated Water 标题:Method For Producing Amides In The Presence Of Superheated Water 摘要:该发明涉及一种生产羧酸酰胺的方法,根据该方法,至少一种具有以下结构的羧酸(i)r3-coon(i)其中r3是氢或含有1至50个碳原子的可选择取代的烃基,与至少一种具有以下结构的胺(II)hnr1R2(II)其中r1和r2独立地是氢或含有1至100个碳原子的可选择取代的烃基,反应形成一种铵盐,然后在超热水存在下,在微波辐射下,将该铵盐反应形成一种羧酸酰胺.
专利号:WO-2025082632-A1 优先权日:2023-10-16 标 题:Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU 权利人:BACHEM HOLDING AG 摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.
专利号:EP-4605403-A1 优先权日:2022-10-17 标 题:Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL 权利人:BACHEM HOLDING AG 摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.
专利号:WO-2024083746-A1 优先权日:2022-10-17 标 题 :Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL 权利人:BACHEM HOLDING AG 摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.
专利号:US-10836710-B2 优先权日:2016-12-05 标 题 :Mechanochemical synthesis of radiographic agents intermediates 发明人:BARGE ALESSANDRO; BARICCO FRANCESCA; CRAVOTTO GIANCARLO; FRETTA ROBERTA; LATTUADA LUCIANO 权利人:BRACCO IMAGING SPA 摘要:The present invention generally relates to a process using a mechanochemical approach exploiting the mechanical milling of reactants for the manufacturing of acetyl Iopamidol and, more generally, of key intermediates of radiographic contrast agents, and of the contrast agents themselves.
专利号:US-11952324-B2 优先权日:2017-08-04 标 题 :Amidoamine synthesis, methods to track the reaction process 发明人:KHRAMOV DIMITRI M; CHEN YIYAN; OKHRIMENKO ALBERT 权利人:MI LLC; SCHLUMBERGER TECHNOLOGY CORP 摘要:Methods may include quantifying the concentration of residual free amine and/or free carboxylic acid in a product mixture prepared from a reaction of a multireactive species and a fatty reagent; verifying that the concentration for the free amine and/or free acid in the product mixture is within an acceptable threshold for a given application; and combining the product mixture with one or more wellbore fluid components to generate the wellbore fluid. In another aspect, methods may include including reacting the multireactive species and a fatty reactant to generate a product mixture; quantifying the concentration of residual free amine and/or free carboxylic acid in the product mixture; verifying that the concentration for the free amine and/or free acid in the product mixture is within an acceptable threshold for a given application; and collecting the product mixture.
专利号:US-9445592-B2 优先权日:2005-12-06 标题:Complex for use in stabilizing herbicidal compositions and methods for synthesizing and using the same 发明人:WU TAI-TEH; EAGLES KAREN L; EDENFIELD MICHAEL W 权利人:BAYER CROPSCIENCE LP 摘要:The present invention is directed to the discovery, isolation, identification and methods of synthesis of a novel chemical complex that can be used to stabilize mixtures of different chemical compounds, and in particular mixtures of different herbicidal compounds.
参考标题:Deoxygenative Hydroboration Of Primary, Secondary, And Tertiary Amides: Catalyst‐free Synthesis Of Various Substituted Amines 作者:Jaeeun Yi,Hyun Tae Kim,Ashok Kumar Jaladi,Duk Keun An |发布日期:2022.1 摘要:Less Reactive Functional Groups Under Catalyst-Free Conditions Is An Interesting Aspect And Requires A Typical Protocol. Herein, We Report The Synthesis Of Various Primary, Secondary, And Tertiary Amines Through Hydroboration Of Amides Using Pinacolborane Under Catalyst-Free And Solvent-Free Conditions. The Deoxygenative Hydroboration Of Primary And Secondary Amides Proceeded With Excellent Conversions
合成参考文献
摘要:American Industrial Hygiene Association Journal., 32(539), 1971 [] 参考文献:10.1007/s11356-012-1198-0 摘要:Čadková E, Komárek M, Kaliszová R, Száková J, Vaněk A, Bordas F, Bollinger J. The influence of copper on tebuconazole sorption onto soils, humic substances, and ferrihydrite. Environmental Science and Pollution Research. 2012 Dec 18;20(6):4205–15. doi: 10.1007/s11356-012-1198-0.