CAS: 1535-75-7; 2-(Trifluoromethoxy)Aniline

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上下游产品

CAS号306935-26-2 8-(三氟甲氧基)-2-(三氟... | CAS号37526-59-3 2-(三氟甲氧基)苯磺酰胺 | CAS号235101-36-7 2-氨基-4-三氟甲氧基苯并噻唑 | CAS号103008-51-1 2-(三氟甲氧基)苯磺酰氯 | CAS号2252-44-0 1-溴-3-(三氟甲氧基)苯 | CAS号175205-33-1 2-(三氟甲氧基)苯基异硫氰酯 | CAS号175278-09-8 4-溴-2-(三氟甲氧基)苯胺 | CAS号149125-30-4 7-三氟甲氧基靛红 | CAS号186386-95-8 1-(2-TRIFLUOROM... | CAS号396075-91-5 7-(三氟甲氧基)-1H-吲哚

邻溴三氟甲氧基苯置于ammonium Hydroxide,2-O-Methyl-L-Inositol,Copper(II) Acetate Monohydrate体系中,用 N-甲基吡咯烷酮 用作溶剂,化学反应 12.0H,以82%的收率获得邻氨基三氟甲氧基苯
参考文献:Quebrachitol 或二甘醇促进的铜 (II)-催化芳基卤化物和 N-亲核试剂的 C-N 偶联
标题:Quebrachitol 或二甘醇促进的铜 (II)-催化芳基卤化物和 N-亲核试剂的 C-N 偶联
摘要:在本文中,我们报告了天然配体 Quebrachitol (Qct) 作为 Cu(II) 催化剂的促进剂,它对各种胺和相关芳基卤化物的 N-芳基化非常有效.通过使用二甘醇(deg)作为配体和溶剂,以高收率获得了一系列二芳胺衍生物.C-N偶联反应在温和的条件下进行并表现出非常好的官能团耐受性.
Doi:10.1055/s-0039-1690707

专利信息

专利号:US-12336981-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; DRAGOVICH Peter; GOSSELIN FRANCIS; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; ROTH BRUCE; SMITH CHASE C; WANG ZHONGGUO; YUEN PO-WAI; ZHENG XIAOZHANG
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

专利号:EP-3560587-A1
优先权日:2018-04-24
标 题:Method for synthesis of a metal organic framework composite

专利号:US-9169209-B2
优先权日:2011-05-04
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and composition for inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:RU-2076108-C1
优先权日:1990-03-07
标题 :Derivatives of n-phenylglycine amide, method of their synthesis and pharmaceutical composition showing affinity to receptors of hck and gastrin

专利号:US-4338318-A
优先权日:1979-03-23
标 题 :Novel compositions and methods
发明人：HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
权利人:ZOECON CORP
摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.