CAS: 3160-59-6; (2S,3S)-2-(((Benzyloxy)Carbonyl)Amino)-3-Methylpentanoic Acid

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上下游产品

CAS号73-32-5 L-异亮氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号2130-99-6 (2S,3S)-4-硝基苯基 ... | CAS号31139-36-3 苄氧甲酸酐 | CAS号1072902-75-0 L-异亮氨酸奥利司他 | CAS号42417-66-3 N-苄氧羰基-N-甲基-L-异亮氨酸 | CAS号3391-99-9 N-(苯基甲氧基羰基)-L-异... | CAS号4125-98-8 N-甲基L-异亮氨酸 | CAS号73-32-5 L-异亮氨酸 | CAS号24787-83-5 z-ile-ala-oh | CAS号13254-04-1 Z-ILE-GLY-OH | CAS号86161-49-1 L-Z-异亮氨酰胺 | CAS号872423-93-3 (3R,4S)-4-methy... | CAS号42537-99-5 L-异亮氨酸-L-异亮氨酸

D-异亮氨酸,苄氧甲酸酐置于sodium Hydroxide体系中,用 1,4-二氧六环 用作溶剂,化学反应生成(2R,3R)-2-(((苄氧基)羰基)氨基)-3-甲基戊酸
参考文献:二酰基甘油脂肪酶活性的测定和抑制
标题:二酰基甘油脂肪酶活性的测定和抑制
摘要:合成了一系列与四氢脂抑素 (Thl) 和 O-3841 结构相关的 β-内酯衍生物的n-甲酰基-α-氨基酸酯,可抑制人和鼠二酰基甘油脂肪酶 (Dagl) 的活性.开发了新的醚脂质报告化合物用于体外测定,以使用荧光共振能量转移 (Fret)有效筛选 1,2-二酰基-Sn-甘油水解和相关脂肪酶活性的抑制剂.利用标记的内源性底物 [1″-14 C]1-Stearoyl-2-Arachidonoyl-Sn-Glycerol 进行二酰基甘油脂肪酶活性的标准化薄层色谱 (Tlc) 放射分析,并通过磷光成像检测通过以下初始形成来量化抑制产品 [1″-14 C]2-花生四烯酸甘油并在测定条件下进一步水解为[1-14 C]花生四烯酸.
Doi:10.1016/j.Bmcl.2012.05.101

专利信息

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:US-4978744-A
优先权日:1989-01-27
标题:Synthesis of dolastatin 10
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:A complicated but extremely important scheme of synthesis has been developed for synthesizing, dolaisoleuine, dolaproine, dolaphenine and dolavaline from readily available starting materials such as Z-(S,S)isoleucine, S-phenylalaline, S-phenylalaninol, S-prolinol, S-mandelate, and S-valine. The requisite amino acids have been combined using several peptide coupling procedures to create pharmaceutically pure dolastatin 10.

专利号:US-3978035-A
优先权日:1973-03-27
标 题 :13-Norleucine-14-desamido motilin, a method for preparing it and an agent containing it
发明人：WUNSCH ERICH; WENDLBERGER GERHARD; JAEGER ERNST; SCHARF REGINE; DEIMER KARL-HEINZ; STOCKER HANS
权利人:MAX PLANCK GESELLSCHAFT
摘要:The specification describes the total synthesis of L-norleucine-13-motilinased on the replacement of the L-methionine radical located in the 13-position by an L-norleucine radical. In accordance with the present day development of peptide synthesis the central arginyl-methionyl-bond (amino acids 12 and 13 of motilin) can in practice hardly be synthesised, while on the other hand the norleucine-13-docosapeptide corresponding to motilin can be more readily produced synthetically, and this provides for a comparatively rapid determination of structure and can give important information as regards the biological effect specificity of methionine.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.