专利号:US-6084108-A 优先权日:1997-10-14 标 题 :Synthesis of 3-carbomethoxy-4,5-dimethylthiophene 发明人:FEVIG THOMAS L; LAU PATRICK H; PHILLIPS WENDELL G 权利人:MONSANTO CO 摘要:Fungicides having thiophene rings may be made from the intermediate compound 3-carbomethoxy-4,5-dimethylthiophene. That compound, and related compounds, may be produced by reacting an alpha mercaptoketone, e.g., 3-mercapto-2-butanone, with an acrylate, e.g., methyl-3-methoxy acrylate, in the presence of an alkoxide base, e.g., NaOMe, to form the substituted tetrahydrothiophene, followed by conversion to the aromatic thiophene with an acid treatment. The substituted tetrahydrothiophene is a novel compound.
专利号:US-2010317886-A1 优先权日:2009-06-11 标 题 :Synthesis of isotopically-labeled functionalized dienes 发明人:MARTINEZ RODOLFO A 权利人:MARTINEZ RODOLFO A 摘要:All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.
专利号:RU-2014320-C1 优先权日:1987-09-15 标题:Method of synthesis of propenoic acid derivatives and their stereoisomers
专利号:WO-9919321-A1 优先权日:1997-10-14 标 题 :Synthesis of 3-carbomethoxy-4,5-dimethylthiophene
专利号:EP-1023283-B1 优先权日:1997-10-14 标 题 :Synthesis of 3-carbomethoxy-4,5-dimethylthiophene
专利号:CN-1116294-C 优先权日:1997-10-14 标 题:Synthesis of 3-methoxy formyl-4, 5-dimethyl thiophene
摘要:Andersson, C.-M.; Andersson, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 8. 摘要:Beingessner, R. L.; Longstreet, A. R.; McTeague, T. A.; Kelly, L. P.; Seo, H.; Tran, T. H.; Wicker, A. C.; Jamison, T. F., Science of Synthesis: Flow Chemistry in Organic Synthesis, (2018) 1, 457. 摘要:Kacprzak, K. M.; Skiera, I.; Rutkowski, J., Science of Synthesis, (2021) , 184. 参考文献:10.1038/nchembio.94 摘要:Ulanovskaya OA, Janjic J, Suzuki M, Sabharwal SS, Schumacker PT, Kron SJ, Kozmin SA. Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. Nature Chemical Biology. 2008 May 30;4(7):418–24. doi: 10.1038/nchembio.94.