CAS: 369-33-5; 1-(3,4-Difluorophenyl)Ethanone

上下游产品

ortho-difluorobenzene acetic anhydride acetyl chloride methylmagnesium chloride 3,4-Difluorobenzoic acid 3-(3,4-difluorophenyl)-3-oxopropanenitrile 3,4-difluorophenacyl bromide ethyl 3-(3,4-difluorophenyl)-3-oxopropanoate

3,4-二氟苯乙炔置于水体系中,化学反应 15.0H,以67%的收率获得3',4'-二氟苯乙酮
参考文献:在末端炔烃直接水合中具有高活性的沸石y纳米粒子组件†
标题:在末端炔烃直接水合中具有高活性的沸石y纳米粒子组件†
摘要:合成了具有微中观大分子结构的强酸性沸石y纳米粒子组件(hnano-Y),与酸性介孔沸石zsm-5和beta催化剂.该特征应归因于以下事实:Hnano-Y中的微-中-大结构有利于质量转移,Hnano-Y上的强酸性部位促进炔烃的水合活性.催化剂可以重复使用六次而不会失去活性.
Doi:10.1039/c6Ra11489J

专利信息

专利号:US-5138088-A
优先权日:1988-06-17
标 题 :Nitrobenzoyl-3-cyclopropylaminoacrylates and a process for the preparation thereof
发明人：KIM YOU SEUNG; PARK SANG WOO; KIM JEA CHEOL
权利人:KOREA ADVANCED INST SCI & TECH
摘要:Nitrobenzoyl-3-cyclopropylaminoacrylates are prepared by two stage reaction: a) The first stage is the synthesis of nitrobenzoyl-3-alkoxyacrylates from nitrobenzoylester compound and alkylorthoformate in organic acid solvent. b) The second stage is the synthesis of nitrobenzoyl-3-cyclo propylamino acrylate from nitrobenzoyl-3-alkoxyacrylates and cyclopropylamine.

专利号:US-10072009-B2
优先权日:2014-10-21
标 题 :N-substituted beta-carbolinium compounds as potent P-glycoprotein inducers
发明人：BHARATE SANDIP; KUMAR AJAY; MANDA SUDHAKAR; JOSHI PRASHANT; BHARATE SONALI; VISHWAKARMA RAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R 1 and R 2 groups are selected from halogens or trifluoromethyl; R 3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R 1 and R 2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.

专利号:US-8513241-B2
优先权日:2008-03-28
标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
发明人：CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-6531471-B2
优先权日:1998-12-17
标 题:Morpholinone and morpholine derivatives and uses thereof
发明人：LAGU BHARAT; NAGARATHNAM DHANAPALAN; TIAN DAKE; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to morpholinone and morpholine derivatives which are selective antagonists for human α 1a receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia, sympathetic mediated pain, migraine, and for the treatment of any disease where the antagonism of the α 1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-6620815-B1
优先权日:1997-06-18
标题:Oxazolidinones and uses thereof
发明人：LAGU BHARAT; DHAR T G MURALI; NAGARATHNAM DHANAPALAN; JEON YOON T; MARZABADI MOHAMMAD R; WONG WAI C; GLUCHOWSKI CHARLES
权利人:SYNAPTIC PHARMA CORP
摘要:This invention is directed to oxazolidinone compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular pressure, inhibiting cholesterol synthesis, relaxing lower urinary tract tissue, the treatment of benign prostatic hyperplasia, impotency, cardiac arrhythmia and for the treatment of any disease where the antagonism of the α 1A receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

专利号:US-9701686-B2
优先权日:2009-12-04
标题:Tricyclopyrazole derivatives
发明人：DISINGRINI TERESA; MANTEGANI SERGIO; VARASI MARIO
权利人:NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.