CAS: 6456-74-2; Tert-Butyl 2-Aminoacetate

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CAS号16881-32-6 N-(Benzyloxycar... | CAS号5292-43-3 溴乙酸叔丁酯 | CAS号1634-04-4 甲基叔丁基醚 | CAS号56-40-6 甘氨酸 | CAS号27532-96-3 甘氨酸叔丁酯盐酸盐 | CAS号6367-36-8 叠氮基乙酸叔丁酯 | CAS号819050-60-7 tert-butyl ((2,... | CAS号1245735-65-2 Fms-Gly-OtBu | CAS号6297-93-4 2-(1,3-二氧代异吲哚啉-... | CAS号540-88-5 醋酸叔丁酯 | CAS号35059-50-8 重氮基乙酸叔丁酯 | CAS号4530-20-5 B°C-甘氨酸 | CAS号5845-68-1 3-bromo-N-[2-me... | CAS号50595-15-8 2-乙醇酸叔丁酯 | CAS号640-68-6 D-缬氨酸 | CAS号72-18-4 l-缬氨酸 | CAS号56-41-7 L-丙氨酸 | CAS号338-69-2 D-丙氨酸 | CAS号2769-72-4 异氰基乙酸乙酯 | CAS号81477-94-3 二苯亚甲基甘氨酸叔丁酯

Tert-Butyl α-Fluoroacetate置于盐酸,Potassium Tert-Butylate体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 2.33H,反应生成 甘氨酸叔丁酯
参考文献:一种甘氨酸叔丁酯的制备方法
标题:一种甘氨酸叔丁酯的制备方法
摘要:本发明公开了一种甘氨酸叔丁酯的制备方法,属于有机合成技术领域.以卤代乙酸叔丁酯为原料与氨基化试剂进行亲核取代,随后在不同条件下脱保护得到甘氨酸叔丁酯,本发明原料易得,流程简便,反应条件温和,对设备要求低,总收率高达85‑93%,有效避免了传统工艺中与氨直接反应时反应生成明显量双取代副产物.

专利信息

专利号:US-2022298204-A1
优先权日:2019-07-05
标题 :Synthesis of a-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:EP-3792250-A1
优先权日:2019-09-13
标题:Synthesis of alpha-amanitin and its derivatives
发明人：SIEGERT MARY-ANN; KNITTEL CAROLINE HERTA; SÃœSSMUTH RODERICH
权利人:PURE BIOORGANICS SIA
摘要:The present invention relates to the chemical synthesis of α-amanitin and its derivatives. The present invention also relates to intermediate products of the α-amanitin synthesis.

专利号:US-5280093-A
优先权日:1989-06-29
标题 :Chiral polymers for the synthesis of pure enantiomers of amino acids
发明人：JACQUIER ROBERT; CALMES MONIQUE; DAUNIS JACQUES
权利人:RHONE POULENC CHIMIE
摘要:The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. n These polymers are characterized in that they comprise: n a chiral unit n a functionalizing unit n an optional crosslinking unit n Application to chiral organic synthesis.

专利号:US-2025091989-A1
优先权日:2023-09-19
标 题 :Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:EP-0535155-B1
优先权日:1990-06-14
标 题:Libraries of modified peptides with protease resistance
发明人：BARTLETT PAUL A; SANTI DANIEL; SIMON REYNA
权利人:CHIRON CORP; UNIV CALIFORNIA
摘要:Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.

专利号:US-6075121-A
优先权日:1990-05-15
标 题 :Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
发明人：SIMON REYNA J; BARTLETT PAUL A; SANTI DANIEL V
权利人:CHIRON CORP
摘要:Peptoids are provided which are polymers comprised of monomer units wherein the monomer units include at least some substitute amino acids and may include conventional amino acids. The peptoids can be synthesized in large numbers so as to provide libraries of peptoids which can be screened in order to isolate peptoids of desired biological activity. Although the peptoids may include amino acids, they preferably include only substituted amino acids and are designed in a manner so as to have a particular biological activity. Certain peptoids are designed to mimic as closely as possible the activity of known proteins. Other peptoids are designed so as to have greater or lesser activity than known proteins and may be designed so as to block known receptor sites and/or elicit a desired immunogenic response and thereby act as vaccines. In that the peptoids are comprised of substitute amino acids they can be designed to have structures which natural proteins cannot conform to. A range of different amino acid substitutes are disclosed, as are their methods of synthesis and methods of using such amino acid substitutes in the synthesis of peptoids and peptoid libraries. Methods of screening the libraries in order to obtain desired peptoids of a particular biological activity are also disclosed. The peptoids are preferably linked to a pharmaceutically active drug forming a conjugate with increased binding affinity to a particular biological receptor site.