苯基溴代乙基硫醚置于水体系中,化学反应生成 2-苯硫基乙醇 参考文献:A Comparison Of The Oxidative Reactivities Of Mustard (2,2'-Dichlorodiethyl Sulfide) And Bivalent Sulfides 标题:A Comparison Of The Oxidative Reactivities Of Mustard (2,2'-Dichlorodiethyl Sulfide) And Bivalent Sulfides 摘要: DOI:10.1021/jo00298A055
专利号:WO-2017033128-A1 优先权日:2015-08-25 标题 :Biphenyl-substitued 4-amino-butyric acid derivatives and their use in the synthesis of nep inhibitors 发明人:HOOK DAVID; KU JIE; ZHOU JIANGUANG 权利人:NOVARTIS AG; HOOK DAVID; KU JIE; ZHOU JIANGUANG 摘要:The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.
专利号:US-7429658-B2 优先权日:2003-09-11 标题 :Synthesis of protected pyrrolobenzodiazepines 发明人:HOWARD PHILIP; MASTERSON LUKE 权利人:SPIROGEN LTD 摘要:A method of synthesis of a N-10 protected PBD compound of formula (I): n nvia an intermediate of formula (II) or formula (V):
专利号:US-6492136-B1 优先权日:1995-12-07 标题 :Solid phase organic synthesis 发明人:FLITSCH SABINE LAHJA; TURNER NICHOLAS JOHN 权利人:GENZYME LTD 摘要:A method of synthesis of a material corresponding to the general formula:characterized in that it comprises a material corresponding to the following general formula:being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R''), C(O)O, S, C(O)N(H) or C(O)N(R''), R'' being a non-interfering group; and Support represents a solid support.
专利号:US-5374743-A 优先权日:1993-09-30 标题 :Process for the synthesis of lactide or glycolide from lactic acid or glycolide acid oligomers 发明人:THAYER CHESTER A; BELLIS HAROLD E 权利人:DU PONT 摘要:A process for preparing lactide or glycolide from a lactic acid oligomer or glycolic acid oligomer is disclosed where the molecular weight of the synthesis reactor residue is controlled to no more than 1.2 times that in the feed. The process is carried out at 130° to 280° C. and preferably 180° to 210° C. using from 1 to 6 weight percent catalyst in the oligomer feed to the synthesis reactor. The catalysts are tin or tin compounds, yttrium or rare earth metal compounds, or antimony compounds which are known as alphahydroxycarboxylic acid cyclic dimerization or polymerization catalysts.
专利号:US-11897853-B2 优先权日:2018-12-31 标题 :Synthesis of 1,1,2-trifluoro-4-(substituted sufonyl)-but-1-ene 发明人:ZELL THOMAS; COHEN SHLOMI 权利人:ADAMA MAKHTESHIM LTD 摘要:The present invention provides a process for preparing a compound of formula [I] from a compound of formula [II] using an oxidizing agent and a catalyst, the process is carried out at a low temperature.
专利号:US-2003138376-A1 优先权日:2000-03-17 标题 :Dosing form for reagents, use of said dosing form in organic chemical synthesis and production of said dosing form 发明人:RUHLAND THOMAS; HOLM PER; SCHULTZ KIRSTEN; HOLM JANNIE EGESKOV; ANDERSEN KIM 权利人:LUNDBECK & CO AS H 摘要:A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the same predetermined amount of said at least one reagent embedded in a polymer matrix comprising beads of a polymer insoluble in the solvents for the intended synthesis, which tablets are capable of disintegrating in said solvent for release of the at least one reagent and disperse the matrix as polymer beads into the solvent. The polymer beads forming the matrix and the reagents of the dosing form can easily be removed by filtration in order to separate these from a formed soluble product. n In a method for producing the dosing form, beads of one or more polymers are mixed with the reagents and compressed into tablets after pre-treatment with an aprotic organic solvent.