CAS: 84-22-0; 2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-Dihydro-1H-Imidazole
该化合物是一种化学化合物,主要以其作为眼科溶液中的热液血管限制器而闻名,属于非碘化化合物,其特点是能够控制血管,从而减少眼睛中的红度.该化合物的分子式反映了其结构,包括双环环系统.它通常作为无色的黄色液体被发现,在水和有机溶剂中溶解.四氢化物对甲型成虫感应器有作用,导致其药理效应.它通常用于超计眼滴,暂时减轻红度和刺激.然而,必须按指示使用它,因为过度使用可能导致红度反弹或其他副作用.该化合物还因其可能被滥用而受到监管审查.
- ⚠️《化妆品禁用原料目录》
- 英文名称2-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4,5-Dihydro-1H-Imidazole
- 中文名称四氢唑林
- IUPAC名称2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole
- 其它别名4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthyl)-1H-imidazole; Tetrahydrozoline; Visine
- CAS编号84-22-0
- MFCD编号:MFCD00216026
- EINECS号:201-522-3
- 分子式:C13H16N2
- 分子量:200.29
- 产品CID: 1830772
- 产品分类原料药 → 神经系统用药 → 拟胆碱药
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS07;
注释: Exclamation mark - 危险类别急性毒性 类别4(经口)
- 警示词Warning(警告)
- 危险描述H302 |吞咽有害.
- 防范说明P280-P305+P351+P338
- 安全声明IDENTIFICATION AND USE: Tetrahydrozoline hydrochloride, an imidazoline derivative, is applied topically to the eye for self-medication to temporarily relieve congestion, itching, and minor irritation, and to control hyperemia in patients with superficial corneal vascularity. Ocular decongestants are ineffective in the treatment of delayed hypersensitivity reactions such as contact dermatoconjunctivitis. The vasoconstrictor effect of tetrahydrozoline may be used during some ocular diagnostic procedures, but some clinicians prefer phenylephrine to tetrahydrozoline for this use. HUMAN STUDIES: Serious adverse events requiring hospitalization have been reported in pediatric patients following accidental ingestion of nonprescription ophthalmic solutions or nasal sprays containing imidazoline derivatives including tetrahydrozoline. Between 1985 and October 2012, 96 cases of accidental ingestion were reported in children 1 month to 5 years of age. The amount of drug ingested ranged from 0.6-45 mL. While no deaths were reported, more than half of these cases reported serious adverse events requiring hospitalization, including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence, mydriasis, stupor, hypothermia, drooling, and coma. ANIMAL STUDIES: In dogs, signs of intoxication may include vomiting, bradycardia, cardiac arrhythmias, poor capillary refill time, hypotension or hypertension, panting, increased upper respiratory sounds, depression, weakness, nervousness, hyperactivity, or shaking. These signs appear within 30 min to 4 hr postexposure. In general, imidazoline decongestant exposure may affect the GI, cardiopulmonary, and nervous systems.
欧盟法规
REACH注册ECHA物质ECHA物质化妆品禁用物质清单REACH预注册上下游产品
1-cyanotetraline ethylene diamine mono-p-toluenesulfonic acid salt ethylenediaminerac-2-(1,2,3,4-tetrahydro-naphthalen-1-yl)-1H-imidazole合成工艺路线路线简述
1-氰基四氢化萘,Ethylene Diamine Mono-P-Toluenesulfonic Acid Salt 反应生成 四氢唑林
参考文献:De1009189
标题:De1009189
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
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杭州市下城区青云街40号5层15室
销售经理: 陈鑫经理
联系电话:86-571-87234293
手机号码: 13429114492
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杭州市下城区青云街40号5层15室
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