CAS: 932-31-0; O-Tolylmagnesium Bromide

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CAS号95-46-5 2-溴甲苯 | CAS号17630-76-1 5-氯靛红 | CAS号53092-64-1 1,4-bis(2-methy... | CAS号106475-19-8 1-bromo-4-(2-me... | CAS号39615-34-4 环丙基2-甲基苯基酮 | CAS号5931-53-3 二苯基(o-甲苯基)膦 | CAS号40138-16-7 2-甲酰基苯硼酸 | CAS号36042-94-1 二邻甲苯基氯化膦 | CAS号606-46-2 N,N-二乙基邻甲苯胺 | CAS号341-39-9 2,2,2-三氟-1-(邻甲苯... | CAS号41870-52-4 2-甲基二苯甲基氯化物

2-溴甲苯置于magnesium,1,2-二溴乙烷体系中,化学反应生成 邻甲苯基溴化镁
参考文献:紫光促进溴吡啶与格氏试剂通过 Set 偶联
标题:紫光促进溴吡啶与格氏试剂通过 Set 偶联
摘要:烷基吡啶和芳基吡啶以及2,2'-联吡啶通常通过吡啶的minisci反应和卤代吡啶的过渡金属催化的偶联反应来制备.在此,首次公开了在普通玻璃器皿中的et 2 O或et 2 O与四氢呋喃的混合物中,紫光促进的2-或4-溴吡啶与格氏试剂的自由基偶联反应,而不需要过渡金属催化剂.甲基,伯烷基和仲烷基,环烷基,芳基,杂芳基,吡啶基和炔基格氏试剂与该方案兼容.结果,很容易制备烷基吡啶和芳基吡啶以及2,2'-联吡啶.紫光刺激从格氏试剂到溴吡啶的单电子转移.格氏试剂二聚过程中挤出的电子充当催化剂.光开/关实验表明产物的形成需要持续的照射.自由基时钟底物的研究证实了来自溴吡啶的吡啶基自由基的参与以及来自格氏试剂的烷基或芳基自由基的不参与.现有证据支持新偶联反应的光诱导 S Rn机制.
DOI:10.1021/acs.Joc.4C00525

专利信息

专利号:US-5998620-A
优先权日:1997-03-25
标 题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of the formula ##STR1## comprising reacting a bromo-substituted pyridine with an amine of the formula NHR 5 R 6 , reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R 1 , R 2 , R 3 and R 4 are as defined in the specification; also claimed are a compound of the formula ##STR2## and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:US-9243004-B2
优先权日:2011-07-22
标题 :Synthesis of boronic esters and boronic acids using grignard reagents
发明人：CLARY JACOB W; SINGARAM BAKTHAN
权利人:CLARY JACOB W; SINGARAM BAKTHAN; UNIV CALIFORNIA
摘要:Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg 0 . When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.

专利号:EP-0977739-B1
优先权日:1997-03-25
标题 :Synthesis of intermediates useful in preparing tricyclic compounds
发明人：CHEN XING; POIRIER MARC; WONG YEE-SHING; WU GUANG-ZHONG
权利人:SCHERING CORP
摘要:The invention relates to a process for preparing a compound of formula (I), comprising reacting a bromo-substituted pyridine with an amine of the formula NHR5R6, reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R?1, R2, R3 and R4¿ are as defined in the specification; also claimed are a compound of formula (a), and a process for preparing it from the corresponding halo-substituted benzoic acid.

专利号:US-2014303333-A1
优先权日:2011-10-14
标题:Iron bisphenolate complexes and methods of use and synthesis thereof
发明人：SHAVER MICHAEL P; KOZAK CHRISTOPHER M
权利人:UNIV PRINCE EDWARD ISLAND; GENESIS GROUP INC
摘要:The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R 1 and R 2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.

专利号:US-2022363662-A1
优先权日:2021-04-20
标题 :Compounds as lxr agonists
发明人：PUJALA BRAHMAM; SATHE BALAJI DASHRATH; DANODIA ABHINANDAN; GUPTA ASHU; SONI SANJEEV; KUMAR VIVEK; ANSARI AMANTULLAH; KHAN FARHA; SARKAR ARINDAM; PAYGHAN PAVAN V
权利人:INTEGRAL BIOSCIENCES PRIVATED LTD
摘要:The present invention generally discloses compounds having LXR (the liver X receptor) agonistic activity, to the use of such compounds in the treatment of various disorders such as proliferative disorders, Alzheimer's disease, inflammatory diseases, and diseases characterized by defects in cholesterol and lipid metabolism. Specifically, the present invention discloses compound of formula (IA) which exhibit LXR agonist activity, specifically to LXRβ. The invention also discloses method of synthesis of said compounds, method of using said compounds, pharmaceutical compositions comprising said compounds and method of using thereof.

专利号:US-2022411375-A1
优先权日:2019-10-18
标题:Process for synthesis of picolinamides