CAS: 937174-76-0; (S)-4-(2-(4-Amino-1,2,5-Oxadiazol-3-yl)-1-Ethyl-7-(Piperidin-3-Ylmethoxy)-1H-Imidazo[4,5-C]Pyridin-4-yl)-2-Methylbut-3-Yn-2-Ol

上下游产品

1,1-dimethylethyl (3S)-3-({[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-4-(3-hydroxy-3-methyl-1-butyn-1-yl)-1H-imidazo[4,5-c]pyridin-7-yl]oxy}methyl)-1-piperidinecarboxylate ethyl-(3-bromo-5-nitropyridin-4-yl)amine 4-ethylpyridine-3,4-diamine5-bromo-2-chloro-N4-ethylpyridine-3,4-diamine (7-bromo-4-chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile

(3-溴-5-硝基-吡啶-4-基)-乙基-胺置于四(三苯基膦)钯 N-甲基吗啉,盐酸,Sodium Nitrate,盐酸羟胺,水,Caesium Carbonate,Isopropyl Magnesium Chloride,1,8-二氮杂双环[5.4.0]十一碳-7-烯,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺,三乙胺,三氟乙酸,Sodium Iodide,Tin(Ll) Chloride,锌体系中,用 四氢呋喃,1,4-二氧六环,甲醇,乙醚,二氯甲烷,水,溶剂黄146,二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 79.34H,反应生成 土大黄甙
参考文献:Wo2008/121685
标题:Wo2008/121685

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:US-12054508-B1
优先权日:2019-04-16
标 题 :Compositions and methods for sulfation of carbohydrates and peptides via electron-deficient aryl sulfate diesters
发明人：NIU JIA; LIU CHAO; YANG CANGJIE
权利人:THE TRUSTEES OF BOSTON COLLEGE
摘要:In one aspect, the disclosure relates to a facile strategy to introduce electron-deficient aryl sulfate diesters to silylated hydroxyl groups of carbohydrates and amino acids, among other substrates, wherein selective hydrolysis and the removal of an electron-deficient aromatic group allows for the efficient generation of sulfated carbohydrates, peptides, and other compounds. The incorporation of electron-deficient aryl sulfate diesters in the early stage of the synthesis of glycans, peptides, and the like, disclosed herein avoids time-consuming protecting group manipulations, simplifies the purification of sulfated products, and improves the overall yield and efficiency. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人：FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:WO-2010062846-A1
优先权日:2008-11-26
标题 :Synthesis of stable organogold compounds and methods of use thereof
发明人：HAMMOND GERALD B; BATES PAULA J; VAISBERG ABRAHAM J; LIU LEPING; XU BO
权利人:HAMMOND GERALD B; BATES PAULA J; VAISBERG ABRAHAM J; LIU LEPING; XU BO
摘要:Disclosed herein are novel gold containing compounds and methods of synthesis and use thereof. The novel compounds are very stable. The stability of the compounds allows for their use in methods of treating cancer cells. Disclosed herein are examples of the use of the compounds to inhibit growth of cancer cell lines. The utility of the compounds disclosed herein is a method of treating cancer cells in which a therapeutically effective amount of a compound is administered.

专利号:US-8193360-B2
优先权日:2003-07-31
标 题:Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18 F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-9949970-B2
优先权日:2010-09-14
标题 :Synthesis of new benzothiazole derivatives as potential anti-tubercular agents
发明人：KAMAL AHMED; SHETTI RAJESH VCRNC; SWAPNA PONNAMPALLI; AZEEZA SHAIK; REDDY A MALLA; KHAN INSHAD ALI; ABDULLAH SHEIKH TASDUQ; SHARMA SANDEEP; KALIA NITIN PAL
权利人:COUNCIL SCIENT IND RES
摘要:Disclosed are compounds of general formula A useful as potential anti-tubercular agents. The general formula A is