乙基三氯硅烷置于rh,Re/c 氢气体系中,700.0 °C,792.91 Kpa 条件下,反应 17.88H,以75.3%的收率获得三氯硅烷 参考文献: Method Of Making A Trihalosilane[fr] Procédé De Fabrication D'Un Trihalosilane 标题: Method Of Making A Trihalosilane[fr] Procédé De Fabrication D'Un Trihalosilane 摘要:制备三卤硅烷的方法包括将符合以下式rs1X3(i)的有机三卤硅烷与氢接触,其中r为c1-C10烃基,每个x独立地为卤素,有机三卤硅烷与氢的摩尔比为0.009:1至1:2300,在选择自re的金属催化剂存在下,在300至800oc下形成三卤硅烷.
专利信息
专利号:WO-2024047178-A1 优先权日:2022-09-02 标题 :A method for simultaneous synthesis of a plurality of oligonucleotides 发明人:ZIV OMER; THORPE CAMERON; TANPURE ARUN; ERLICH YANIV 权利人:ELEVEN THERAPEUTICS LTD 摘要:Disclosed is a method and compounds useful for performing said method for simultaneous synthesis of a plurality of oligonucleotide molecules, and more specifically for orthogonal synthesis of at least two different oligonucleotide molecules at the same time with applications in combinatorial chemistry and DNA encoded libraries (DEL).
专利号:US-2012165565-A1 优先权日:2009-09-01 标题 :Synthesis of fluorocarbofunctional alkoxysilanes and chlorosilanes 发明人:MARCINIEC BOGDAN; MACIEJEWSKI HIERONIM; DUTKIEWICZ MICHAL; DABEK IZABELA; KARASIEWICZ JOANNA 权利人:MARCINIEC BOGDAN; MACIEJEWSKI HIERONIM; DUTKIEWICZ MICHAL; DABEK IZABELA; KARASIEWICZ JOANNA; UNIV ADAM MICKIEWICZ 摘要:The subject of invention is the method of synthesis of fluorocarbofunctional alkoxysilanes and chlorosilanes of the general formula HCF 2 (CF 2 ) n (CH 2 ) m OC 3 H 7 SiR 1 R 2 R 3 in which -n takes values from 1 to 12, m takes values from 1 to 4,—R 1 stands for an alkoxy group or halogen, if R 1 stands for an alkoxy group, then R 2 and R 3 can be the same or different and stand for an alkoxy group containing C=1-4, alkyl group containing C=1-12 or an aryl group, if R 1 stands for a halogen, then R 2 and R 3 can be the same or different and stand for based on hydrosilylation of an appropriate fluoroalkyl-allyl ether with an appropriate trisubstituted silane of the general formula HSiR 1 R 2 R 3 in the presence of siloxide rhodium complex [{Rh(OSiMe 3 )(cod)} 2 ] as a catalyst.
专利号:US-10173993-B2 优先权日:2015-12-09 标题 :Process for the synthesis of sulfones and sulfonamides 发明人:VON WOLFF NIKLAS; CHAR JOËLLE; CANTAT THIBAULT 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:A one pot single step process is described for the synthesis of a compound, including a labeled compound, containing a sulfonyl functional group comprising the step of mixing together a silane, an SO 2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. A process for producing tracers from a labeled sulfonyl containing compound prepared by the described process is also included.
专利号:US-5455367-A 优先权日:1993-04-22 标 题:Method for the synthesis of silanes or organosilicon hydrides by the reduction of the corresponding silicon halides or organosilicon halides 发明人:KLEIN KLAUS-DIETER; KNOTT WILFRIED; KOERNER GOETZ 权利人:GOLDSCHMIDT AG TH 摘要:A method for the synthesis of silanes or organosilicon hydrides by the reduction of the corresponding silicon halides or organosilicon halides with a magnesium hydride in a liquid reaction medium is carried out by utilizing the following distinguishing features: n a) the use of non-pyrophoric, preferably autocatalytically produced, storage magnesium hydride as magnesium hydride, n b) the use of conventional ethers as reaction medium, and n c) the continuous removal of the magnesium halide formed being deposited on the surface of the magnesium hydride particles during the reaction by the action of mechanical energy or ultrasound so as to form a fresh surface.
专利号:US-5679773-A 优先权日:1995-01-17 标题 :Reagants and methods for immobilized polymer synthesis and display 发明人:HOLMES CHRISTOPHER P 权利人:AFFYMAX TECH NV 摘要:Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, beta -turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.
专利号:US-9303055-B2 优先权日:2001-03-14 标题 :Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports 发明人:GAO XIAOLIAN; ZHANG HUA; YU PEILLIN; LEPROUST ERIC; PELLOIS JEAN PHILIPPE; XIANG QIN; ZHOU XIAOCHUAN 权利人:UNIV MICHIGAN; UNIV HOUSTON 摘要:A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.
摘要:Wang, K. K., Science of Synthesis, (2008) 44, 268. 摘要:Roy, K.-M., Science of Synthesis, (2010) 47, 902. 摘要:Wicha, J., Science of Synthesis, (2009) 48, 106. 摘要:Koo, S., Science of Synthesis, (2010) 45, 1365. 摘要:Aitken, R. A.; Aitken, K. M., Science of Synthesis, (2010) 47, 1049.