CAS: 1191237-69-0; (2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-yl)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Carbonitrile

相似化合物

1355357-49-1 1191237-80-5 1355049-94-3

上下游产品

(3R,4R,5R)-2-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-yl)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-Carbonitrile 1191237-68-9
瑞德西韦相关化合物5 (2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-yl)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-Carbonitrile 1355357-49-1
7-((2S,3S,4R,5R)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-yl)Pyrrolo[2,1-F][1,2,4]Triazin-4-Amine 158227-80-6
瑞德西韦杂质1 (3R,4R,5R)-2-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-yl)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-Ol 1355049-94-3
(2S,3R,4R,5R)-2-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-yl)-3,4-Bis(Benzyloxy)-5-((Benzyloxy)Methyl)Tetrahydrofuran-2-Ol

Tert-Butyl N-[7-[(2R,3R,4S,5R)-2-Cyano-3,4-Dihydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]Pyrrolo[2,1-F][1,2,4]Triazin-4-Yl]Carbamate置于盐酸体系中,用 异丙醇 用作溶剂,化学反应 1.0H,以0.95 Mmol的收率获得瑞德西韦母核
参考文献:N-保护的杂环类化合物,其制备方法及其用于制备c-核苷衍生物的方法
标题:N-保护的杂环类化合物,其制备方法及其用于制备c-核苷衍生物的方法
摘要:本发明提供了n‑保护的杂环类化合物,其制备方法及其用于制备c‑核苷衍生物的方法.具体地,本发明提供了一种使用n‑苄氧羰基或n‑叔丁氧羰基保护的杂环类化合物来制备c‑核苷衍生物的方法.本发明方法无需进行卤代,无需进行氨基临时保护,直接使用有机锂或有机镁化合物脱除杂环类化合物的质子,与核糖内酯进行加成.本发明的方法不仅缩短了c‑核苷衍生物的合成路线,而且在没有卤原子作为取代基的情况下,杂环类化合物与核糖内酯的反应获得了显著提高的收率.

专利信息

专利号:US-5041526-A
优先权日:1988-05-16
标 题:Dimer for synthesis of high performance polymer matrix composites
发明人：RIEL FRANK J; VUONG TUYET; DELANEY EDWARD A
权利人:ROHR INDUSTRIES INC
摘要:An improved synthesis for PMR-type polyimides, including first preparing a dimer of 5-norbornene-2,3-dicarboxylic acid, or acid ester or anhydride and 4,4'methylene dianiline. This dimer is then reacted with one of the following: n 1. the reaction product of a primary aromatic diamine and an aromatic dianhydride. n 2. an aromatic dianhydride. n 3. a mixture of a primary aromatic diamine and an aromatic dianhydride, or an ester of an aromatic tetraacid or an aromatic tetraacid. n The resulting polyimide prepolymer exhibits superior physical properties and is substantially free of undesired impurities and unreacted 4,4'-methylene dianiline.

专利号:US-11612614-B2
优先权日:2020-10-20
标题:Isomorphs of Remdesivir and methods for synthesis of same
发明人：TRIPATHI VINAY SHANKAR; PATEL AKSHAY NIKHIL
权利人:ANZALP PHARMASOLUTIONS PVT LTD
摘要:A new isoform of 2-ethylbutyl (2S)-2-[[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3/4-dihydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate (Remdesivir) having increased water solubility is disclosed, along with methods for making the same. Also disclosed are solid and liquid pharmaceutical compositions suitable for treating viral infections such as Arenaviridae, Coronaviridae, Filoviridae, Flaviviridae, or Paramyxoviridae viral infections which contain an effective amount of Remdesivir prepared according to the inventive method and the use of those compositions for treating such viral infections.

专利号:US-2025115610-A1
优先权日:2021-08-03
标 题:Process for the catalytic glycosylation of arenes
发明人：LIST BENJAMIN; OBRADORS CARLA; MITSCHKE BENJAMIN; AUKLAND MILES
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention refers to a process for the catalytic glycosylation of arenes which allows, amongst others, the expeditious synthesis of the nucleoside analogue GS-441524 of the antiviral prodrug remdesivir.

专利号:WO-2024193457-A1
优先权日:2023-03-20
标题:Preparation method of pyrrolotriazine compound
发明人：ZHENG CHENGUANG; GUO SONGJING; ZHAO REN; PAN RUI; WANG TAO; TANG PINGSHENG; JIN YEHUA; ZHU WEI; MENG YANHUA
权利人:ZHEJIANG HUAHAI PHARM CO LTD
摘要:The present invention belongs to the field of drug synthesis, and more specifically relates to a preparation method of a pyrrolotriazine compound, specifically comprising: firstly reacting compound 2 with NaH and TMSCl to protect the amino group, and then reacting with compound 3 under the action of n-butyl lithium to obtain compound 4; compound 2 can be obtained by reacting compound 1 with a bromination reagent, and compound 1 can be recovered. The method of the present invention is simple to operate, low in cost, and more conducive to industrial production.

专利号:US-11155675-B2
优先权日:2016-07-27
标 题:Method of regioselective synthesis of polyesters from asymmetric diols
发明人：NODARI MIRCO; LONGO ALDO; COLONNA MARTINO; GIOIA CLAUDIO
权利人:VERSALIS SPA
摘要:A method for synthesizing regioregular polyesters, starting from asymmetric diols, may provide the polymer ordered structure and advantageous physical-chemical properties. Such methods can make it is possible to obtain regioregular polyesters having high glass transition temperatures T g and crystalline properties. In the case in which the asymmetric diols are used in a pure enantiomeric form, with respect to the chiral carbon bound to the secondary hydroxyl, through the above-mentioned method it is possible to obtain regioregular and stereoregular polyesters, which may have thermal and crystalline properties further ameliorative with respect to non-chiral regioregular polymers.

专利号:US-2021161927-A1
优先权日:2020-10-20
标 题:Isomorphs of remdesivir and methods for synthesis of same