CAS: 1358581-37-9; (2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol

英文名称(2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol
中文名称(2S,3R,4S,5S,6R)-2-(3-((5-(4-氟苯基)-2-噻吩)甲基)-4-甲苯基)-6-(羟甲基)-2-甲氧基-2H-3,4,5-三羟基四氢吡喃
IUPAC名称(2S,3R,4S,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
其它别名(2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-Tetrahydro-6-(Hydroxymethyl)-2-Methoxy-2H-Pyran-3,4,5-Triol; Methyl 1-C-[3-[[5-(4-Fluorophenyl)-2-Thienyl]Methyl]-4-Methylphenyl]-Alpha-D-Glucopyranoside; (2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-Tetrahydro-6-(Hydrox; (2S,3R,4S,5S,6R)-2-[3-[[5-(4-Fluorophenyl)-2-Thienyl]Methyl]-4-Methyl-Phenyl]-6-(Hydroxymethyl)-2-Methoxy-Tetrahydropyran-3,4,5-Triol; (2S,3R,4S,5S,6R)-2-(3-((5-(4-Fluorophenyl)Thiophen-2-yl)Methyl)-4-Methylphenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol; 2-Methoxy Canagliflozin; Canagliflozin 1-Methoxy; Canagliflozin-4
CAS编号1358581-37-9
MFCD编号:MFCD28978477
FDA UNII编号:4X975B8M4V
分子式:C25H27FO6S
分子量:474.55
产品CID: 560264
产品分类分析化学 → 标准品 → 药典标准品和杂质标准品

相似结构搜索
InChIKey: UKGXVMIGVXOCSH-HFBCXCLPSA-N
InChI=1S/C25H27FO6S/c1-14-3-6-17(25(31-2)24(30)23(29)22(28)20(13-27)32-25)11-16(14)12-19-9-10-21(33-19)15-4-7-18(26)8-5-15/h3-11,20,22-24,27…
计算化学: 氢键受体数8.0氢键供体数4.0可旋转键数6.0

MSDS等安全信息

上下游产品

methanesulfonic acid (5-bromo-2-chloro-phenyl)-[5-(4-fluorophenyl)-2-thienyl]methanone (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 5-bromo-2-chlorobenzoic acid (2S,3R,4S,5S,6R)-6-[(tertbutyl(dimethyl)silyl)oxymethyl]-2-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methyl-phenyl]-2-methoxy-tetrahydropyran-3,4,5-triol [[(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methyl-phenyl]-6-methoxy-tetrahydropyran-2-yl]methoxy]tert-butyl-dimethyl-silane [(2R,3R,4S,5R,6S)-3,4,5-tribenzyloxy-6-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methyl-phenyl]-6-methoxy-tetrahydropyran-2-yl]methanol (2S,3S,4S,5R,6S)-3,4,5-tribenzyloxy-6-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methyl-phenyl]-6-methoxy-tetrahydropyran-2-carbaldehyde

合成工艺路线路线简述

(3R,4R,5R)-5-[(1R)-1,2-二羟基乙基]-3,4-二羟基四氢呋喃-2-酮置于n-甲基吗啉,叔丁基锂体系中,用四氢呋喃,甲苯,正戊烷用作溶剂,化学反应 3.0H,反应生成(2S,3R,4S,5S,6R)-2-(3-((5-(4-氟苯基)-2-噻吩)甲基)-4-甲苯基)-6-(羟甲基)-2-甲氧基-2H-3,4,5-三羟基四氢吡喃
参考文献:一种sglt-2抑制剂化合物的制备方法
标题:一种sglt-2抑制剂化合物的制备方法
摘要:本发明涉及一种sglt-2抑制剂化合物的制备方法,利用化合物a通过羟基保护,偶联反应,羟基脱保护,缩酮反应步骤得到中间体ⅰ,再通过得到的中间体ⅰ制备sglt-2抑制剂化合物.